معرفی
Apurba Dutta is an Associate Professor and Interim Chair in the Department of Medicinal Chemistry at the University of Kansas School of Pharmacy. His research focuses on asymmetric synthesis of bioactive molecules, development of synthetic methodologies, and natural product-based drug discovery. He holds a Ph.D. in Chemistry from North-Eastern Hill University (1989) and completed postdoctoral research at the University of Kansas (1994) and a Humboldt Fellowship at the University of Konstanz (1992).
Research Overview: Dr. Dutta’s work includes total synthesis of antifungal peptidyl nucleosides (e.g., polyoxins, nikkomycins), proteasome inhibitors like salinosporamide A, and cytotoxic marine natural products. He also explores combinatorial libraries of biomimetic compounds (nucleosides, azacarbohydrates) for high-throughput screening.
Key Projects: His lab investigates antifungal agents targeting chitin synthase, endotoxin sequestration for septic shock, and proteasome inhibition for cancer therapy. Notable contributions include synthetic routes to Jaspine B and structural studies of polyoxamic acid.
Publications: Recent work includes stereoselective iminosugar synthesis (2025), SAR analyses of lipopeptides (2010), and neurochemical studies of enantiomers (2016). Over 100 publications span medicinal chemistry, organic synthesis, and drug discovery.
Awards & Recognition: While no specific awards are listed, his contributions to antibiotic design and synthetic methodology reflect sustained excellence in the field.
Current Activity: Not currently accepting students/postdoctoral fellows, but actively engaged in grant-funded research projects focused on antifungal agents and combinatorial chemistry.
