معرفی
Dr Antoni Borysik is a Senior Lecturer in the Department of Chemistry at King's College London, within the Faculty of Natural, Mathematical & Engineering Sciences. He specializes in biomolecular mass spectrometry, particularly hydrogen-deuterium exchange (HDX-MS) and native MS, to study protein conformations and dynamics. His roles include MRes Director, PGT Admissions Tutor, and Advanced Analytical Chemistry Module Lead.
Education: PhD from the University of Leeds, where he pioneered methods for characterizing amyloidogenic proteins using mass spectrometry. Prior to King's, he was an industrial fellow at the University of Oxford with Waters Corporation.
Research focuses on biomolecular structure and dynamics, including natively unfolded proteins, liquid-liquid phase separation, and protein deposition disorders. The Borysik Group develops computational tools like HDXmodeller for high-resolution HDX-MS analysis and explores AI applications in structural biology.
Recent work emphasizes ensemble-based models for protein conformations and machine learning for HDX-MS data correction. Over 20 years of experience in biomolecular characterization has led to advancements in structural elucidation of protein assemblies and membrane proteins.
Supervises PhD students including Chloe Bailey, Sabrina Hossain, Alexandros Gkounta, and Joanna Toporowska. Active in grants such as the BBSRC-funded 'Simulated isotope exchange patterns for protein structure determination' and projects with Micromass UK Ltd.
Labs and teams: The Borysik Group collaborates on hybrid structural biology approaches, integrating MS with molecular dynamics simulations. Projects include structural analysis of protein complexes and development of detergent-based methodologies for gas-phase protein stabilization.
