معرفی
Antonella De Matteis serves as Full Professor of Biology at the University of Naples Federico II and Principal Investigator/Program Coordinator for the Cell Biology and Disease Mechanisms at TIGEM. She holds faculty positions at the European School of Molecular Medicine (SEMM) and Open University PhD Programme in Human Genetics, directing cutting-edge research at the intersection of membrane dynamics and human disease.
Her educational foundation includes an M.D. from the University of L’Aquila with dual residencies in Internal Medicine and Endocrinology. This clinical background informs her translational research approach.
De Matteis's research centers on membrane trafficking mechanisms and membrane contact sites, with emphasis on phosphoinositide signaling at the Golgi complex. Her work elucidates how trafficking defects drive Mendelian disorders (Lowe syndrome, ALS8) and viral pathogenesis (SARS-CoV-2), revealing therapeutic targets through molecular dissection of FAPP proteins, VAPB, and OCRL pathways.
Publication trends demonstrate evolutionary progression from fundamental trafficking mechanisms (FAPP2 in glycosphingolipid synthesis) to disease applications (Mendelian disorders) and emerging viral threats, consistently published in Nature, Science, and NEJM.
Key recognition includes:
- ERC Advanced Grant for Systems Biology of Membrane Trafficking (SYSMET, 2016)
She mentors 4 PhD students and 7 postdoctoral fellows while securing major grants including ERC SYSMET (2016-2022), FNIH AAV trafficking studies (2022-2024), and AIRC cancer-related membrane contact site research (2018-2024).
Her TIGEM laboratory integrates cell biology, genetics, and drug discovery to develop therapies for rare diseases, maintaining active collaborations with clinical and industrial partners.
