معرفی
Professor Janet Deane is a Professor of Membrane Biology and Wellcome Trust Senior Research Fellow at the University of Cambridge, where she leads a research group at the Cambridge Institute for Medical Research (CIMR) within the School of Clinical Medicine. Her laboratory is part of the Department of Clinical Neurosciences and focuses on understanding the molecular mechanisms by which altered sphingolipid metabolism results in devastating neurological diseases.
Her research explores the connections between rare genetic neuropathologies and common neurodegenerative diseases, with the goal of laying scientific foundations for future therapies. Professor Deane's work falls under several strategic CIMR themes including Membrane Trafficking, Rare Genetic Disease, and Neurological Disease.
Her laboratory investigates how changes in glycosphingolipid metabolism affect cell function, particularly in the context of neurological disorders. The research employs a range of techniques including structural biology, cell biology, and biochemistry to understand membrane dynamics and lipid metabolism in health and disease. Her recent publications reveal a strong focus on ganglioside synthesis, membrane remodeling in genetic disorders like GM2 gangliosidoses (Tay-Sachs disease), and the intersection of lipid metabolism with viral pathogenesis.
- Wellcome Trust Senior Research Fellow
- Principal Investigator at Cambridge Institute for Medical Research
- Member of Department of Clinical Neurosciences
Professor Deane collaborates with several prominent researchers including Dr. David Gershlick, Professor Evan Reid, Professor Julian Rayner, and Professor Randy J. Read. Her laboratory currently includes research group members Henry Barrow, Ella Bishop, Zhuang (George) Han, Shannon McKie, Holly Monkhouse, Alex Nicholson, and Jack Welland.
