Anne O'Garra

Professor Anne O'Garra holds the Chair in Infection Immunology at the National Heart & Lung Institute, part of the Faculty of Medicine at Imperial College London. Her research focuses on immune system regulation, particularly cytokines like IL-10 and type I interferons, to understand their roles in infections such as tuberculosis (TB). Based in the United Kingdom, she leads a laboratory investigating mechanisms of immune response modulation and pathogenesis in bacterial infections.

Her work includes identifying a gene signature linked to TB progression and recovery, involving type I interferon-inducible genes. Research explores how IL-10 balances immune protection and tissue damage, with studies spanning human cohorts, cell models, and mouse infection models. Collaborative efforts aim to uncover therapeutic targets for chronic infections like TB, leveraging interdisciplinary approaches in immunology and microbiology.

Key areas of expertise include cytokine regulation, host-pathogen interactions, and translational research linking basic immunology to clinical outcomes. Her findings contribute to understanding both protective immunity and immunopathology in infectious diseases.