Anne Maass

Anne Maass is a Researcher at the German Center for Neurodegenerative Diseases (DZNE), Magdeburg, leading multidisciplinary studies at the intersection of Alzheimer's disease, neuroimaging, and cognitive resilience. Her work focuses on molecular mechanisms of aging using in vivo multimodal imaging techniques.

• Key affiliations: DZNE Magdeburg, Otto von Guericke University, SFB1436 "Neural Resources of Cognition"
• Collaboration network: Prof. Emrah Düzel (Magdeburg), Prof. Michael Heneka (Bonn), Prof. Stefanie Schreiber (Magdeburg), Prof. Sylvia Villeneuve (Montreal)

Her research integrates functional and structural MRI (3T/7T), PET imaging with novel tracers like PI-2620, and cerebrospinal fluid proteomics to map tau pathology, Aβ accumulation, and vascular contributions to cognitive decline. She pioneered Vessel Distance Mapping for quantitative hippocampal vascularization analysis.

Recent publication trends emphasize inflammatory signatures (TAM receptors, sTREM2), non-linear fMRI activation patterns in preclinical Alzheimer's, and vascular compensation mechanisms for neurodegenerative pathology. Her work on SuperAgers investigates neural resources for exceptional cognitive aging through multimodal cohort studies.

Current projects include:

• SFB1436 Z03: Molecular imaging of aging and SuperAgers
• DELCODE study: Longitudinal tracking of Alzheimer's biomarkers
• Collaborative network: Cross-site studies with Bonn, Göttingen, and Barcelona

Her translational research aims to develop intervention strategies for neuroinflammatory regulation and cognitive reserve enhancement to prevent age-related cognitive decline.