Anna Grosberg

Anna Grosberg, Ph.D., is an Associate Professor and Core Lab Faculty Director in the Department of Biomedical Engineering at the University of California, Irvine (UCI). She leads the Cardiovascular Modeling Laboratory, part of the UCI Edwards Lifesciences Foundation Cardiovascular Innovation and Research Center (CIRC). Her work focuses on integrating computational modeling and tissue engineering to study cardiac development, function, and disease mechanisms, particularly leveraging stem cell-derived cardiomyocytes and in vitro/in silico models.

Her research interests include multiscale modeling of cardiac structure-function relationships, mechanobiology of cardiac tissue, and translational applications in regenerative medicine. Key topics involve hypoxia effects in obstructive sleep apnea, genetic cardiomyopathies (e.g., LMNA mutations), and the biophysical basis of cardiac contractility. Collaborations span engineering, medicine, and industry to develop tools for drug discovery, medical devices, and personalized treatments.

Dr. Grosberg has pioneered platforms like the 'Heart on a Chip' and developed quantitative methods for assessing cytoskeletal changes in diseases such as lung cancer and muscular dystrophy. Her educational contributions include the CardioStart program, a virtual tissue engineering course for high school students.

Her lab emphasizes interdisciplinary innovation, combining experimental assays with advanced modeling to address cardiac disease at cellular, tissue, and organ levels. Current projects explore how mechanical forces influence myogenesis, the role of microtubules in muscle fiber integrity, and predictive models for OSA severity assessment.