معرفی
Benjamin L. Prosser is an Associate Professor of Physiology at the Perelman School of Medicine, University of Pennsylvania, where he serves as Associate Director of the Pennsylvania Muscle Institute and Director of the Center for Epilepsy and NeuroDevelopmental Disorders (ENDD). His research bridges cardiovascular mechanobiology and neurodevelopmental disorders, focusing on microtubule dynamics in heart failure and antisense oligonucleotide therapies for STXBP1/SYNGAP1-related epilepsy.
- Ph.D. in Molecular Medicine, University of Maryland School of Medicine (2009)
- B.S. in Health and Exercise Science, Wake Forest University (2005)
His cardiovascular research explores how microtubules regulate cardiomyocyte mechanics, nuclear integrity, and myocardial stiffness in diseases like LMNA cardiomyopathy and heart failure with preserved ejection fraction. Key findings include the role of tubulin tyrosination in cardiac function and the development of anti-microtubule therapeutics.
In neurodevelopmental disorders, Prosser collaborates with patient advocacy groups to model and treat STXBP1 and SYNGAP1 mutations, leveraging his daughter's diagnosis to drive translational efforts. His lab integrates data from 534 STXBP1 cases to define clinical signatures.
The 15 most recent articles (2025-2022) highlight dual expertise in cardiac mechanotransduction and neurogenetics, with a focus on microtubules, antisense oligonucleotides, and stress response pathways.
Labs & Collaborations include the Prosser Lab, the Center for Epilepsy and NeuroDevelopmental Disorders, and partnerships with Ionis Pharmaceuticals for RNA-targeted therapies.
