Anna-Franziska Worthmann

Dr. Anna-Franziska Worthmann is a researcher at the Department of Biochemistry and Molecular Cell Biology at the University Medical Center Hamburg-Eppendorf. With a doctoral degree in natural sciences (Dr. rer. nat.), she has established herself as a prominent researcher in the field of lipid metabolism and its implications in various diseases.

Her research primarily focuses on:

• Lipid and cholesterol metabolism
• Fatty acid synthesis and its regulatory mechanisms
• Adipose tissue biology and thermogenesis
• The role of lipid metabolism in diseases such as Acute Myeloid Leukemia (AML), Non-Alcoholic Fatty Liver Disease (NAFLD), and cardiovascular conditions
• Metabolic adaptations to environmental stimuli like cold exposure

Dr. Worthmann's publication record demonstrates a strong trajectory in understanding the molecular mechanisms of lipid metabolism. Her recent work has increasingly focused on the intersection of lipid metabolism with cancer biology, particularly in AML, as evidenced by multiple 2025 publications examining fatty acid synthase inhibition in leukemia with specific mutations. She also maintains active research in maternal metabolism and its impact on offspring, as well as circadian aspects of metabolic responses.

Her methodological expertise spans advanced techniques including:

• Liquid chromatography-tandem mass spectrometry for metabolite quantification
• In vivo metabolic studies using animal models
• Analysis of lipidomic and bile acid profiles
• Investigation of signaling pathways in metabolic diseases