معرفی
Dr. Angie Sin is a Researcher at the University of Glasgow's School of Cardiovascular & Metabolic Health. She specializes in cardiovascular and metabolic research, focusing on enzyme regulation (e.g., PDE4, arginase-1) and their roles in disease pathogenesis. Her work spans drug development, molecular biology, and translational medicine. She holds an email address: Angie.Sin@glasgow.ac.uk.
Research Interests:
- Cardiovascular biology, including hypertrophy and vasoprotective mechanisms
- Metabolic disorders and enzyme dysfunction (e.g., arginase-1 deficiency)
- Protein degradation pathways and targeted therapies
- Signal transduction in cardiac and neuronal cells
Recent Publications (2024–2025):
Her recent studies include vasoprotective mechanisms via angiotensin-endothelin receptor interactions, novel PDE4 degradation strategies using proteolysis-targeting chimeras, and collagen IV's role in small vessel disease. These contributions highlight advancements in drug design and disease modeling.
Grants & Funding:
- Medical Research Council (2024–2025): Developing 3D culture systems for validating phosphodiesterase-4 inhibitors
Collaborations & Teams:
Dr. Sin collaborates with institutions like the University of Glasgow’s labs, focusing on interdisciplinary projects involving cardiology, biochemistry, and pharmacology.
