معرفی
Professor George Baillie is a faculty member at the University of Glasgow, holding the position of Professor of Molecular Pharmacology within the College of Medical, Veterinary and Life Sciences (CVMLS) and associated with the School of Cardiovascular & Metabolic Health. His academic journey includes a BSc (Hons) in Botany (1988) and a PhD in Protein Biochemistry from the University of Kent (1993). He has held roles as a Postdoctoral Fellow (1995-2006), Lecturer (2007-2010), Reader (2010-2013), and Professor (2013-present).
- Research Focus: Cardiac diseases, compartmentalization of PDE4 isoforms, post-translational modifications of cardiac signaling proteins, and inhibition of protein-protein interactions for therapeutic applications.
- Key Research Groups: Cellular Signaling & Mechanisms, Arrhythmias, Heart Failure, and Hypertension.
- Key Collaborations: Works with institutions like FBLS Glasgow, CVMLS, and international teams on projects involving cAMP signaling, phosphodiesterases, and protein interactions.
His research explores how PDE4 isoforms regulate β-adrenergic signaling in cardiac diseases, with implications for developing targeted therapies. He investigates mechanisms such as ubiquitin proteasome pathways and the role of cAMP signaling in pathologies like heart failure and hypertension. His work bridges molecular pharmacology with clinical applications in cardiovascular health.
Key themes in his publications include PDE4 isoforms as therapeutic targets, protein interactions (e.g., calpain, DHX9), and the role of cAMP in neurological and oncological contexts. Ongoing research focuses on novel drug strategies involving proteolysis targeting chimeras and understanding disease mechanisms via phosphodiesterase dysfunction.
