معرفی
Andrzej Stasiak is an Associate Professor at the University of Lausanne (UNIL), affiliated with the Center for Integrative Genomics (CIG) within the Faculty of Biology and Medicine. He holds a PhD from the Polish Academy of Sciences (1981) and has held postdoctoral positions at ETH Zurich and the Laboratory of Ultrastructural Analysis at UNIL. His research focuses on understanding the physical and biological mechanisms underlying genome organization, including DNA topology, chromatin structure, and protein knotting. He is a SIB Group Leader (2015) and has contributed to groundbreaking studies on topological domains (TADs), DNA supercoiling, and knotting mechanisms in proteins and DNA.
Education:
- PhD in Biochemistry, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw (1981)
- Postdoctoral Fellow, Institute for Cell Biology, ETH Zurich (1981–1989)
Research Interests:
- Mechanisms of TAD formation via transcription-induced supercoiling
- Effects of DNA crowding on supercoiling and transcription
- Biological mechanisms of DNA unknotting and decatenation
- Role of knotting in protein structure and function
Publications: Over 100 peer-reviewed articles, including studies on DNA topology, protein knotting, and computational models of chromatin organization. Recent work focuses on theta-curves in proteins, topological constraints in DNA replication, and knot classification.
Awards:
- Swiss Institute of Bioinformatics (SIB) Group Leader status (2015)
Lab & Collaborations: Leads a group at CIG with expertise in computational biology, including members such as Fabrizio Benedetti and Julien Dorier. Collaborates on projects like KnotProt, a database of knotted proteins.
