معرفی
Andrew Scott Allen is a Professor of Biostatistics & Bioinformatics at Duke University, where he also serves as Chief of the Division of Integrative Genomics and Director of the Center for Statistical Genetics and Genomics. He is affiliated with the Duke Center for Human Genetics and the Duke Clinical Research Institute.
His research focuses on developing statistical methods for mapping susceptibility loci in complex diseases, integrating genetics, statistics, and computer science. Key contributions include haplotype inference, de novo mutation analysis, and rare variant association testing. He leads the development of software tools like fitDNM, rvTDT, and JAGUAR for genetic data analysis.
- Education: PhD in Biostatistics from Emory University (2001)
His 15 most recent publications (2013-2015) emphasize statistical genetics, genomic data analysis, and haplotype sharing in diseases like epilepsy and amyotrophic lateral sclerosis. Grants from NHLBI, NIH, and Amicus Therapeutics support his work on genetic determinants of disease, functional annotation, and computational methods.
Notable software contributions include:
- fitDNM: Functional de novo mutation testing
- rvTDT: Rare variant transmission disequilibrium test
- JAGUAR: eQTL mapping
Current lab members include Charlotte Nelson, YU JianG, and CHAITANYA ACHARYA. Former students include Karen He (Duke undergraduate, 2013), Min He, and Chuanhua Xing (now assistant professors). Collaborators span institutions like Centers for Disease Control and Prevention and Emory University.
