معرفی
Professor Andrew McMichael is a distinguished academic in the Nuffield Department of Medicine at the University of Oxford. With over 50 years of experience in immunology, he has been pivotal in elucidating T cell immune responses, particularly focusing on HLA-restricted CD8 T cells and their role in HIV infection and vaccination strategies.
- Professor of Molecular Medicine
- Member of Nuffield Department of Medicine
- Collaborator with OHSU's Louis Picker
His research spans three decades, transitioning from influenza to HIV studies, and currently centers on HLA-E restricted immune responses and their potential in universal immunotherapies. Key areas include:
- Analysis of early immune responses in HIV infection
- Investigation of viral escape mechanisms through epitope mutation
- Development of CMV-vectored SIV vaccines with HLA-E restricted T cells
- Structural studies of HLA-E-peptide complexes using crystallography and SAXS
- Exploration of non-classical HLA molecules in immune regulation
- Translational approaches to harness cellular immunity for vaccine design
Publications highlight his team's work on HLA-E ligand diversity, NK cell modulation, and HLA-B*27 autoimmunity connections. Collaborations with Adrian Hill, Sarah Gilbert, and Tomas Hanke demonstrate his integrative approach to medical science.
His laboratory continues to pioneer research on virus-specific and tumor-specific HLA-E restricted T cells, aiming to develop broadly applicable immunotherapies due to HLA-E's limited polymorphism.
