Andrew McMahon

Andrew McMahon is a Research Professor at the California Institute of Technology, focusing on stem cell biology and regenerative medicine. He also serves as the Director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at the Keck School of Medicine of USC.

• Research Focus: Mechanisms of kidney stem/progenitor cell maintenance and differentiation.
• Techniques: Genetic/genomic approaches, high-resolution imaging, spatial transcriptomics, seqFISH technology.
• Applications: Regenerative medicine strategies for kidney injury and disease.

Recent studies from the McMahon Lab explore Wnt signaling in nephron development, sexual dimorphism in kidney gene expression, and comparative kidney development between mice and humans. These investigations leverage cutting-edge tools like microfluidic systems and organoid modeling to advance synthetic kidney research.

As a principal investigator, McMahon has secured funding through the USC Broad Innovation Award for cross-institutional collaborations with labs such as Long Cai's at Caltech. His former lab members including Alex Qiuyu Guo (now at Amgen) and Helena Bugacov (MD candidate) continue to apply their training in STEM careers.

The McMahon Lab maintains active research in kidney regeneration, with recent publications appearing in Nature Communications, Development, and Developmental Cell. Their work has implications for building artificial kidneys from stem cells through the Synthetic Kidney Consortium.