معرفی
Andrew J. Henderson is a Professor at the Boston University Chobanian & Avedisian School of Medicine, holding roles as Assistant Dean of Graduate Medical Sciences and Co-Director of the BU PREP post-bac program. His primary research focuses on cellular mechanisms regulating HIV replication and transcription, with emphasis on T cell signaling, latency, and inflammatory processes. He earned his B.S., M.S., and Ph.D. in Microbiology from the University of California, Riverside.
Research Interests: Dr. Henderson investigates how T cell signals and transcriptional machinery control HIV expression, particularly mechanisms underlying latency and viral persistence. His lab explores pathways involving CD28 costimulation, RNA polymerase II elongation, and chromatin modifications. These studies provide insights into broader topics like signal transduction, immune dysfunction, and inflammatory disorders.
Key Contributions: His work includes identifying transcriptional checkpoints (e.g., NELF and Pcf11 factors), characterizing opioid use’s impact on HIV reservoirs, and developing CRISPR-based tools for HIV repression. He has also contributed to training programs in Liberia and Uganda through initiatives like the BU-UL Partnership and Fogarty grants.
Awards: Notable recognitions include the Boston SciCafe Award, NIH study section leadership, and postdoctoral fellowships from the Leukemia Society of America and Aaron Diamond Foundation.
Grants & Labs: Active grants include NIH-funded investigations into HIV latency, opioid effects on reservoirs, and global health partnerships (e.g., BULEEVR in Liberia). His lab collaborates with institutions like the Providence/Boston CFAR and the BU CTSI.
