معرفی
Dr. Andrej Fabrizius is a Postdoctoral Researcher at the Institute of Animal Cell and Systems Biology within the Department of Biology, University of Hamburg. As a Participating Researcher in the DFG-funded project "Generation of zebrafish Knock-Outs via Crispr/Cas-System", he specializes in molecular physiology and globin protein research across aquatic and terrestrial vertebrates.
- Research Focus: Respiratory proteins (neuroglobin, cytoglobin, androglobin)
- Key Techniques: CRISPR/Cas9 gene editing, RNA-Seq, qRT-PCR, Western Blot
- Primary Affiliation: University of Hamburg (Faculty of Mathematics, Computer Science and Natural Sciences)
His research combines molecular genetics with environmental physiology, creating novel insights through two major projects: (1) Functional analysis of neuroglobin in mammalian CNS using conditional knockouts, and (2) Generation of zebrafish globin KO models to study in vivo functions under stress regimes. This work has produced 21 publications in high-impact journals.
Scientific contributions span marine mammal physiology (whale brain aerobic capacity, seal brain neuroprotection), estuarine ecosystem dynamics (Elbe/Odra estuary fish populations), and fundamental globin biology. Recent work demonstrates how environmental stressors (hypoxia, turbidity, parasitic load) alter physiological systems at molecular and ecosystem levels.
As a translational researcher, Dr. Fabrizius connects molecular mechanisms (gene expression, oxidative stress response) with ecological implications (fish stock health, estuarine monitoring programs). His evolutionary perspective extends from studying Neoceratodus forsteri (Australian lungfish) genome to mammalian diving adaptations.
