معرفی
Andrei Alexandrov is an Assistant Professor in Clemson University’s Department of Genetics and Biochemistry and runs a research lab within the Clemson Center for Human Genetics in Greenwood, SC. He teaches advanced courses such as GEN 8900 Special Topics on Non-Coding RNAs and actively mentors doctoral research assistants.
Education & Training
- PhD, Biophysics, University of Rochester, 2003
- MS, Biophysics, University of Rochester, 2000
- Post-doctoral Research, RNA Biology & Genetics, University of Rochester, 2003-2005
- Post-doctoral Research, RNA Biology & Genetics, Yale University, 2005-2010
Research Focus
The Alexandrov group couples large-scale CRISPR mutagenesis to high-throughput cell-sorting platforms (FACS) to perform forward genetic screens in human cells. The lab’s primary interest is decoding disease-linked RNA pathways—especially those governing non-coding RNAs like MALAT1 and the ribonuclease MRP complex—that become dysregulated in cancer and in inherited disorders carrying premature termination codons.
Recent methodological advances include a bacteria-free eukaryotic expression system (patent pending, 2024) and a fluorescence-amplification forward-genetics pipeline (patent granted 2021) that enables genome-wide discovery of factors involved in mRNA degradation and ncRNA surveillance.
Recent Publications Trend
Over 2024-2025 the group published first-author studies in Cell Reports and Nature Communications that identify previously elusive protein components of human ribonuclease MRP and chart new nuclear ncRNA-regulatory pathways, underscoring an intensifying focus on high-impact mechanistic RNA biology.
Patents & Translation
- U.S. Patent US11,060,153 B2 (2021) – Fluorescence amplification method for forward genetic discovery of factors in human mRNA degradation
- U.S. Patent Application 18/949,053 (2024) – Bacteria-free approach for expressing nucleic acids and proteins in eukaryotic cells
Contact & Resources
Dr. Alexandrov welcomes collaboration inquiries. His lab web portal is www.alexandrovlab.com and institutional profile can be found at Clemson profile page.
