Andreas Ladurner

Andreas Ladurner is Professor and Chair of Physiological Chemistry at Ludwig Maximilian University of Munich (LMU), leading research at the Biomedical Center Munich. His laboratory investigates molecular mechanisms of chromatin dynamics, DNA repair, and metabolic regulation through biochemical and structural approaches.

Research Focus:

• Chromatin biology and epigenetic regulation via histone variants (e.g., macroH2A)
• ADP-ribosylation signaling in DNA damage response and PARP functions
• Chromatin remodelers (ALC1/CHD1L) and their roles in genome stability
• Development of targeted inhibitors for cancer therapy
• Metabolic-epigenetic crosstalk in nuclear compartmentalization

His recent work emphasizes PARP-ALC1 interactions in DNA repair, chemical probe development for macrodomains, and FACT-mediated heterochromatin dynamics. Publications demonstrate consistent focus on chromatin plasticity mechanisms with therapeutic applications in oncology.