Anand Ramasubramanian and John Lee

Anand Ramasubramanian and John Lee are Professors at San José State University, affiliated with the Charles W. Davidson College of Engineering. Ramasubramanian is in the Department of Chemical Engineering, and Lee is in the Department of Mechanical Engineering. They lead a collaborative research initiative focused on the biomechanics of blood clots, integrating mechanical, chemical, and biomedical engineering disciplines.

Their research investigates how structural components within blood clots contribute to mechanical strength under blood flow forces. The team, composed entirely of undergraduate and graduate students, designed and built a microextensometer to apply micrometer-scale displacements and measure clot resistance. Advanced microscopy techniques are used to analyze the distribution and nature of clot components, aiming to understand how microscale features influence macroscopic mechanical behavior.

Their work lies at the intersection of engineering and biology, addressing challenges in cardiovascular disease and stroke treatment. This interdisciplinary approach equips students with valuable skills for both advanced studies and engineering careers.

Their research outputs, while not detailed in individual publications here, center on biomechanics, microdevice development, and tissue-level analysis. The findings have potential clinical relevance in improving thrombolytic therapies and mechanical clot removal procedures.

• No scientific awards are mentioned in the provided text.

Both professors actively mentor students through hands-on research, providing training in experimental design, instrumentation, and interdisciplinary collaboration. Although specific grants are not named, their work is supported by the SJSU Research Foundation, indicating external or institutional funding. The project emphasizes student-led innovation and real-world engineering problem solving.

The research is conducted within a collaborative lab environment involving students from multiple engineering disciplines. The team focuses on building custom instrumentation and applying engineering principles to biological systems, functioning as an interdisciplinary research group within the College of Engineering.