Ana deCarvalho

Ana deCarvalho is an Adjunct Associate Professor at Wayne State University School of Medicine's Department of Pharmacology and Associate Scientist at Henry Ford Health. She holds a PhD from Florida State University and leads research on high-grade gliomas using patient-derived models that capture tumor genomic diversity.

Her laboratory investigates therapy resistance mechanisms through molecular profiling of glioblastoma stem-like cells and orthotopic xenografts. Current projects examine oncogene amplification via extrachromosomal DNA and aberrant developmental pathways like Sox2/MET signaling that drive tumor plasticity.

Publication analysis reveals consistent focus on glioblastoma molecular subtyping, treatment resistance biomarkers, and preclinical model development. Recent works explore epigenetic evolution patterns and interferon signaling impacts on standard therapies.