معرفی
Samir Amin is an Associate Research Scientist in the Department of Neurosurgery at Yale School of Medicine, where he works in the Verhaak Lab focusing on comparative genomics of brain tumors. His research bridges computational biology and clinical neuro-oncology with a particular emphasis on evolutionary patterns in spontaneous canine and human gliomas.
Dr. Amin's primary research interests include comparative genomics, cancer evolution, genomic instability, and therapeutic resistance mechanisms in brain tumors. His work utilizes high-throughput sequencing, computational analysis, and functional studies to decode evolutionary history of gliomas and identify evolutionarily constrained genetic elements that drive tumor progression. He has made significant contributions to understanding how tissue-specific selection pressures influence brain tumor development and response to therapy.
His research portfolio demonstrates consistent focus on cancer genomics, with recent publications examining whole genome doubling, extrachromosomal DNA, mutation signatures, and comparative analysis across species. His work often integrates computational approaches with biological validation to identify therapeutic vulnerabilities in aggressive cancers.
Dr. Amin has collaborated extensively with leading researchers including Roel Verhaak (8 publications), Kevin Johnson (4 publications), and Marcus Bosenberg (3 publications), contributing to major cancer genomics initiatives including The Cancer Genome Atlas Pan-Cancer analysis project.
His laboratory work is conducted at the Verhaak Lab in Sterling Hall of Medicine at Yale, where the team investigates brain tumors and extrachromosomal oncogene DNA amplification, with particular focus on tumor evolution and therapy resistance mechanisms.
