معرفی
Ana Luisa Perdigoto, MD, PhD, is an Assistant Professor in the Department of Internal Medicine at Yale School of Medicine, specializing in Endocrinology. She is affiliated with the Diabetes Research Center and the Janeway Society, reflecting her focus on physician-scientist development and diabetes research.
Education:
- MD, Vanderbilt University School of Medicine (2012)
- PhD, Vanderbilt University School of Medicine (2010)
- BS, Brown University (2001)
- Postdoctoral fellow, Yale School of Medicine (2021)
- Clinical fellow, Yale School of Medicine (2016)
- Resident, Yale New Haven Hospital (2014)
- Intern, Yale New Haven Hospital (2013)
Dr. Perdigoto's research centers on the intersection of immunology and endocrinology, particularly autoimmune diabetes triggered by immune checkpoint inhibitors used in cancer therapy. Her work investigates the immunological mechanisms, genetic predispositions (including germline variants), and beta cell responses that lead to this serious adverse event. She also studies broader aspects of type 1 diabetes immunology and checkpoint inhibitor-related endocrinopathies like hypophysitis.
Her recent publications (2021–2024) reveal a strong trend in translational research, moving from clinical observations to mechanistic studies. The articles focus on identifying genetic risk factors, understanding immune cell interactions with beta cells, characterizing autoantigens like citrullinated glucokinase, and exploring epigenetic regulation (e.g., Tet2) in beta cell responses to inflammation.
Scientific Awards:
- Iva Dostanic Physician-Scientist Trainee Award (2021)
Dr. Perdigoto collaborates extensively with leading researchers at Yale, including Kevan Herold, Harriet Kluger, and David Schoenfeld. Her work is supported by her position within Yale’s robust research infrastructure, including the Diabetes Research Center and the Yale Center for Clinical Investigation. She contributes to the training and mentorship environment as a member of the Janeway Society, which fosters the development of future physician-scientists.
Research Collaborators (Frequent Co-Authors):
- Harriet Kluger, MD
- David Schoenfeld, MD, PhD
- Kevan Herold, MD
- Marie Robert, MD
- Mei-Ling Yang, PhD
- Adebowale Adeniran, MD