Amy Sobbe

Dr. Amy Sobbe serves as an Adjunct Lecturer at the School of Pharmacy and Pharmaceutical Sciences, University of Queensland, where she contributes to academic instruction while maintaining an active research profile in hepatology and pharmacology. Her work bridges pharmaceutical sciences with clinical liver disease research through the University's medical research ecosystem.

Education:

• PhD in Medicine, The University of Queensland (2014)

Research Interests:

Dr. Sobbe specializes in hepatic fibrosis mechanisms, antifibrotic drug development, and iron metabolism dysregulation in cholestatic liver diseases. Her research employs the Mdr2-/- mouse model to investigate molecular pathways of fibrogenesis, evaluate therapeutic agents including mTOR inhibitors and iron chelators, and explore biliary transport's role in hepatic iron homeostasis. This work provides critical insights into disease progression and potential clinical interventions for conditions like primary sclerosing cholangitis.

Publication Trends:

Her 2008-2015 publications reveal consistent focus on translational liver research, with evolving emphasis from rapamycin's antifibrotic mechanisms (2008-2009) to iron dysregulation in cholestasis (2012-2013) and comprehensive antifibrotic therapy evaluation (2015). The research demonstrates strong interdisciplinary collaboration across gastroenterology, pharmacology, and molecular biology, with significant contributions to understanding why certain therapies fail in established fibrosis.

Scientific Awards:

• No scientific awards were documented in available sources

Advising and Grants:

While specific student supervision details are unavailable, her PhD research and publications indicate experience mentoring junior researchers. No grant funding information appears in public records, though her work aligns with NHMRC priorities in liver disease. Her collaborative network includes prominent hepatologists at Greenslopes Private Hospital and international bioiron researchers.

Labs and Teams:

Dr. Sobbe conducted research within the University of Queensland's liver disease research group, collaborating with the Safe and Effective Medication Collaborative and OPTMED-D initiative. Her experimental work centered on the Mdr2-/- mouse model at Greenslopes Private Hospital facilities, contributing to the School's focus on medication optimization in chronic disease management.