معرفی
Amy Andreotti holds the Roy J. Carver Chair and serves as a University Professor in the Department of Biochemistry, Biophysics, and Molecular Biology at Iowa State University. Her research focuses on structural and regulatory mechanisms of Tec family kinases like ITK and BTK, using nuclear magnetic resonance (NMR) and biochemical approaches to investigate immune signaling pathways and disease-related dysregulation.
Amy Andreotti’s educational background includes:
- A.B. in Chemistry and Studio Art from Bowdoin College (1989)
- Ph.D. in Chemistry from Princeton University (1994)
- Postdoctoral Fellowship at Harvard University (1994–1997)
Research Interests: Her work explores how structural features of Tec kinases govern their activity, with a focus on proline isomerization, interdomain interactions, and phospholipid binding. She studies these kinases’ roles in T-cell and B-cell signaling and develops targeted inhibitors to modulate their activity in diseases like chronic lymphocytic leukemia. NMR spectroscopy and structural biology are central to her methods, enabling detailed analysis of kinase conformational dynamics and substrate recognition.
Publications Trends: Recent work emphasizes BTK’s clinical inhibitors and resistance mechanisms in cancer, alongside structural studies of Tec kinases. Earlier research highlighted ITK’s regulation by cyclophilin A and calmodulin, and the role of SH3-SH2 domain interactions in kinase activation. Her studies often integrate biochemical, structural, and computational methods to bridge basic and translational research.
- Roy J. Carver Chair (Endowed Professorship)
Advising & Grants: No formal advisees are listed. While specific grants aren’t detailed, her research likely involves funding for drug development and structural biology projects. She collaborates with pharmaceutical researchers and biotechnology groups to advance therapeutic strategies targeting kinase dysfunction.
Labs & Teams: Her research is conducted within the facilities of Iowa State University’s Roy J. Carver Department, leveraging resources like the Office of Biotechnology and MBB Conference Rooms. She participates in interdisciplinary initiatives such as the Stupka Research Symposium and Graduate Learning Community to foster collaborative research in structural biology and pharmacology.
