معرفی
Mark Hargrove is the Roy J. Carver Professor and Department Chair of Biochemistry, Biophysics and Molecular Biology at Iowa State University. He also holds the Morrill Professor title. His research focuses on heme proteins, exploring their structure, function, folding, and interactions with diatomic ligands like O2, CO, and NO using advanced techniques such as site-directed mutagenesis and X-ray crystallography.
- Education:
- B.S. in Chemistry and Biology, University of Nebraska (1992)
- Ph.D. in Biochemistry, Rice University (1995)
- Postdoctoral Fellow, Rice University (1995–1998)
His research integrates structural biology and biophysics to dissect molecular recognition mechanisms in heme proteins. The Hargrove Laboratory employs cutting-edge methods including kinetic studies, spectroscopy, and computational modeling to unravel how these proteins achieve functional specificity. Recent work emphasizes novel signaling roles of understudied heme proteins and their roles in oxygen storage.
- Awards:
- Roy J. Carver Professorship
- Morrill Professorship
While no specific grants or advisees are listed, his lab’s interdisciplinary approach bridges biochemistry and biophysics. The group collaborates extensively with facilities like the Office of Biotechnology at Iowa State, leveraging state-of-the-art X-ray crystallography resources. Future directions include exploring heme protein dynamics under physiological conditions.
Labs/Teams: Research is conducted in the Hargrove Laboratory, part of the Department of Biochemistry, Biophysics and Molecular Biology.
