معرفی
Todd E. Scheetz is a Professor of Ophthalmology and Visual Sciences, Electrical and Computer Engineering, and Biomedical Engineering at the University of Iowa, where he also holds the Roy J. Carver, Jr. Chair in Bioinformatics and Computational Biology. His interdisciplinary work bridges engineering, genetics, and vision science.
Education:
- BS in Electrical Engineering, University of Iowa
- MS in Electrical and Computer Engineering, University of Iowa
- PhD in Genetics, University of Iowa
Dr. Scheetz's research focuses on bioinformatics and computational systems for analyzing genotype-phenotype relationships. His lab uses next-generation sequencing and large-scale image datasets (up to tens of terabytes) to discover novel endophenotypes in ocular diseases. Key areas include drusen phenotypes, optic nerve morphology, gene expression patterns, mutation detection, and regulatory genomics. He applies machine learning and algorithmic analysis to advance precision ophthalmology.
His recent publications highlight trends in polygenic risk scoring for glaucoma, machine learning-based prediction of disease onset, CRISPR gene therapy in glaucoma models, and functional genomics of LOXL1 in exfoliation syndrome. These works reflect a strong integration of genetics, computational biology, and clinical ophthalmology.
Scientific Awards:
- The Roy J. Carver, Jr. Chair in Bioinformatics and Computational Biology
Dr. Scheetz is actively involved in research mentorship and grant-funded projects, though specific students and grants are not listed. He is affiliated with major research institutes including the Institute for Vision Research, Holden Comprehensive Cancer Center, and the Iowa Institute of Human Genetics. His work is instrumental in advancing genetic diagnostics and computational tools for eye disease.
Research Affiliations:
- Center for Bioinformatics and Computational Biology
- Holden Comprehensive Cancer Center
- Institute for Vision Research
- Iowa Institute for Biomedical Imaging
- Iowa Institute of Human Genetics
- John and Marcia Carver Nonprofit Genetic Testing Laboratory
- Genetics Graduate Program
- Neuroscience Center
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