Amit Tripathi

Amit Tripathi is a Research Assistant Professor at the University of North Texas Health Science Center's College of Biomedical and Translational Sciences, affiliated with the Department of Microbiology, Immunology & Genetics. He holds a PhD from Jawaharlal Nehru University and completed postdoctoral training at the University of North Dakota and UNT Health Science Center. His research focuses on designing short peptides as therapeutic agents for cancer and sepsis, particularly targeting the MIEN1 signaling pathway and antimicrobial peptides with reduced cytotoxicity to normal cells. Key techniques include molecular biology assays (e.g., ELISA, qPCR), in vivo mouse models, and peptide design against multidrug-resistant pathogens. Current projects include developing inhibitors for metastatic TNBC and exploring annexin A2 as a predictive biomarker for chemotherapy responsiveness. His work spans translational cancer research, immunomodulation, and structural peptide analysis.

Research interests include anticancer peptides, structural motifs (e.g., GXXXXG and phenylalanine zippers), and translational applications of peptides in cancer and infectious disease. Notable contributions include first-in-class MIEN1-targeted peptides and MD2-derived peptides that neutralize LPS-induced sepsis. Recent articles emphasize peptide-based therapies, nanoparticle drug delivery, and biomarker discovery. He collaborates on grants like the UNTHSC Foundation-funded project on inhibitory peptides for TNBC.

Lab activities involve peptide design, cancer cell line maintenance, and biochemical assays (e.g., HPLC, fluorescence). His expertise bridges basic science and clinical applications, with a focus on overcoming challenges in cancer metastasis and antibiotic resistance.