Amin Derouiche

Prof. Dr. Amin Derouiche is a Professor in the Institute of Anatomy II – Experimental Neurobiology at Goethe University Frankfurt, Faculty of Medicine. His research focuses on glia-synapse interactions, particularly the structural plasticity of perisynaptic astrocyte processes and their role in synaptic function and disease.

• Studied astrocytic processes using immunofluorescence, live microscopy, and immuno-electron microscopy
• Investigated astrocytic organelles contributing to gliotransmitter release
• Translated findings from rodent models to human brain relevance

Research Interests:
His work addresses the dynamic structural changes of astrocytic processes in response to neural activity, circadian rhythms, and neuroendocrine signals. Key areas include synaptic microenvironment regulation, vesicular release mechanisms, and mitochondrial roles in astrocyte function, leveraging advanced imaging techniques like 3D reconstructions and deconvolution microscopy.

Publication Trends:
His recent research emphasizes astrocyte biology, structural plasticity, and neuroenergetics, with methodological innovations in glial cell imaging. Topics span from basic cellular neuroscience to translational studies relevant to human pathologies.

Technical Expertise:
High-resolution light microscopy, immuno-electron microscopy, live-cell imaging, and transfection techniques with GFP/siRNA constructs are central to his laboratory’s workflow.