معرفی
Alexei Bygrave is an Assistant Professor in the Department of Neuroscience at Tufts University School of Medicine. His research focuses on the molecular mechanisms underlying synapse function, particularly in glutamatergic synapses of GABAergic inhibitory interneurons. He holds a PhD from the University of Oxford and a B.Sc. in Biochemistry from the University of Bristol.
Education:
- Doctor of Philosophy (2016), University of Oxford
- Biochemistry B.Sc. (2016), University of Bristol
Research Interests:
Dr. Bygrave investigates cell-type-specific synaptic mechanisms, with a focus on identifying proteins like Btbd11 that regulate inhibitory interneuron synapses. His work combines genetic mouse models, molecular biology, biochemistry, and live-cell imaging to explore synaptic plasticity and dysfunction in neurological disorders such as schizophrenia. His lab emphasizes translating molecular findings into potential therapeutic strategies for circuit-level dysfunction.
Lab Activities:
- Development of CRISPR-based genome editing tools for neurons
- Proteomic analysis of synaptic components under experience-driven conditions
- Optogenetic interrogation of circuit dysfunction in schizophrenia models
Awards: None explicitly listed in provided texts.
Collaborations: Engages with interdisciplinary teams across neuroscience, genetics, and pharmacology to advance understanding of synaptic mechanisms and their clinical implications.
