معرفی
Alexander V Misharin serves as Associate Professor in the Department of Medicine (Pulmonary and Critical Care) at Northwestern University's Feinberg School of Medicine. He directs research at the Center for Human Immunobiology and Institute for Augmented Intelligence in Medicine, with affiliations spanning the Simpson Querrey Institute for Epigenetics, Northwestern Scleroderma Program, and Robert H. Lurie Comprehensive Cancer Center.
His educational background includes:
- MD from Russian State Medical University (2002)
- PhD from Russian Academy of Medical Sciences (2004)
- Pediatrics Residency at Russian State Medical University (2004)
- Postdoctoral Fellowship in Endocrinology at Cedars-Sinai Medical Center (2008)
Dr. Misharin's research focuses on pulmonary immunology and interstitial lung disease pathogenesis, particularly in scleroderma and post-COVID conditions. His lab investigates macrophage biology in fibrotic lung diseases using single-cell technologies and develops machine learning models for critical care applications. Current work integrates immunobiology with AI to predict disease progression in systemic sclerosis-associated ILD.
His recent publications demonstrate a strong trend toward translational computational medicine, combining immunological profiling with predictive analytics. Key themes include machine learning applications in extubation prediction, pharmacokinetic modeling for ICU antibiotics, and biomarker discovery for scleroderma lung disease.
Dr. Misharin leads the active clinical trial Molecular Biomarkers to Guide Therapy in Systemic Sclerosis-Associated Interstitial Lung Disease (IRB STU00218939), investigating blood, lung fluid, and skin biomarkers to personalize SSc-ILD treatment. He participates in Northwestern's $12 million NIH-funded lung neutrophil research initiative and contributes to the Simpson Querrey Lung Institute for Translational Science.
