معرفی
Huanxing Sun is an Assistant Professor in the Department of Pulmonary, Critical Care & Sleep Medicine at Yale School of Medicine. His research focuses on understanding the molecular and cellular mechanisms underlying pulmonary fibrosis, with particular emphasis on mitochondrial DNA signaling, Toll-like receptor pathways, and neuroimmune interactions in lung disease. Dr. Sun holds a PhD from the Chinese Academy of Medical Sciences (2009) and has contributed to over 30 peer-reviewed publications.
- Primary Appointment: Yale School of Medicine
- Secondary Affiliation: Interstitial Lung Disease Program
Research interests include:
- Mechanisms of fibroproliferative responses in idiopathic pulmonary fibrosis and scleroderma-associated ILD
- Role of extracellular mitochondrial DNA in driving inflammation and fibrosis
- Neuroendocrine regulation of lung fibrosis via adrenergic signaling
- Development of translational models to study fibrotic microenvironments
Recent work demonstrates that α1 adrenoreceptor antagonism reduces mtDNA-driven fibrosis, while TLR9 inhibition shows promise in mitigating fibroblast activation. Collaborations with Erica Herzog, Wonnie Ryu, and Maor Sauler highlight multidisciplinary approaches to lung disease research.
Key contributions include discoveries linking mitochondrial stress to fibrotic progression, and the role of netrin-1/GRB2 signaling in fibrocyte accumulation. Ongoing studies explore biomarkers for disease progression and novel therapeutic targets in fibrotic lung diseases.