معرفی
Alexander Kros is a Full Professor and group leader of the Supramolecular & Biomaterials Chemistry (SBC) group at the Leiden Institute of Chemistry, Faculty of Science, Leiden University, Netherlands. He has held academic positions at Leiden since 2002, progressing from Assistant to Associate and Full Professor in 2016. His research bridges supramolecular chemistry and biomaterials, with a focus on drug delivery and membrane fusion.
His research interests lie at the intersection of supramolecular chemistry, biomaterials, and nanomedicine. He investigates the molecular mechanisms of membrane fusion using biomimetic model systems and applies this knowledge to design advanced drug delivery platforms. His work particularly emphasizes peptide-based systems, liposomes, and lipid nanoparticles for targeted and stimuli-responsive delivery, with applications in cancer therapy and gene delivery. He employs techniques in self-assembly, chemical biology, and nanotechnology to engineer smart nanocarriers.
The recent publications highlight a strong trend in developing innovative, biologically inspired delivery systems. His group focuses on enhancing targeting (e.g., via protein corona analysis, Stab2 evasion), enabling controlled release (e.g., light-triggered fusion, dePEGylation), and improving transfection efficiency (e.g., using inverted lipid phases). The research spans from fundamental supramolecular design to in vivo validation using models like zebrafish.
- NWO XL (M€ 3), with NKI and AMC (2022)
- NWO XS (k€ 50) (2021)
- NWO Groot investering (M€ 2), co-applicant with TUE (2021)
- Cofund OLife (k€ 664) (2020)
- DSM Nutrional Products AG, Switzerland (k€ 103) (2019)
- PPS programma Immunologie “afweer in balans”, Consortium budget (M€ 5) (2018)
- KWF (k€ 420), with AMC (2018)
- TKI-programmatoeslag (k€ 35) (2017)
- NWA Origin fellowship (k€ 200) (2017)
- Huygens fellowship (k€ 200) (2017)
- M-ERA (k€ 613), with NIC and TUE (2016)
Alexander Kros has supervised over 60 PhD students and 6 postdoctoral fellows since 2010, demonstrating a strong commitment to mentoring. He has secured substantial competitive funding, reflecting the impact and innovation of his research. His group, the SBC group, is a key part of the Fundamental Research in Chemical Biology division at LIC. He is also deeply involved in academic service, including chairing MSc exam committees, serving on the Scientific Council of LIC, and reviewing for major funding bodies like ERC and NWO, as well as top journals such as Nature Chemistry and JACS.
