معرفی
Alexander Buffone is an Assistant Professor in the Department of Bio-Medical Engineering at the New Jersey Institute of Technology (NJIT). His research focuses on understanding the mechanisms of cell migration, immune cell trafficking, and glycobiology-driven cancer progression. Recent work includes studies on macrophage migration under shear flow and the role of sialylation in tumor mechanics.
Key research interests include leukocyte biology, cell adhesion cascades, and the interplay between glycocalyx composition and cancer progression. His lab employs microfluidic assays and CRISPR-Cas9 gene editing to investigate cellular processes in inflammatory and oncological contexts.
Notable contributions include a 2024 study revealing how macrophages can migrate upstream against shear flow when Mac-1 is inhibited, and a 2020 review on glycocalyx's role in tumor progression. His team has secured $265K in grants from the New Jersey Health Foundation for health innovation projects.
Collaborations span immunology, bioengineering, and oncology. Current work explores upstream migration mechanisms and the therapeutic potential of modulating glycosylation pathways in cancer treatment.
