معرفی
Professor Albert CM Ong is Professor of Renal Medicine at the University of Sheffield's School of Medicine and Population Health, where he directs specialist services for autosomal dominant polycystic kidney disease (ADPKD) and other genetic kidney diseases at the Sheffield Kidney Institute. A globally recognized expert in ADPKD research, he serves as Co-Director of the MRC-NIHR UK Renal Ciliopathies National Network (CILIAREN) and previously contributed to the European Renal Association Council.
Ong studied medicine at the University of Oxford and trained as a clinician-scientist at University College London and Oxford. His research has focused on the molecular basis of cyst formation, the genetic basis for disease variability, and drug discovery in ADPKD. The Ong lab investigates cyst initiation through studies of PKD1, PKD2, and related proteins within the polycystin network, while also examining non-coding RNAs and RNA metabolism in cyst expansion.
His publication portfolio demonstrates consistent advancement in understanding ADPKD mechanisms and clinical management. Recent work emphasizes AI applications for kidney volume measurement, novel therapeutic targets including glucosylceramide synthase inhibitors, and international consensus on kidney disease management. His research bridges basic molecular mechanisms with clinical translation, employing human cellular models, model organisms, computational modeling, and analysis of deeply phenotyped clinical cohorts.
- Recipient of the ISN Lillian Jean Kaplan International Prize for contributions to ADPKD research
- Held senior research fellowships from Kidney Research UK and the Wellcome Trust
- Extensive involvement in international clinical guideline development
Professor Ong continues to provide strategic leadership in the kidney field through his roles in major research networks and clinical consortia. His work has established the Sheffield Kidney Institute as a leading center for ADPKD research and specialized clinical care, with particular expertise in complex genetic kidney disorders and the development of novel therapeutic approaches.
