Alan David D'Andrea

Dr. Alan David D'Andrea is the Alvan T. and Viola D. Fuller American Cancer Society Professor of Radiation Oncology at Harvard Medical School and Dana Farber Cancer Institute. His laboratory investigates molecular signaling pathways regulating the DNA damage response in mammalian cells, focusing on chromosome instability syndromes like Fanconi Anemia, Ataxia-Telangiectasia, and Bloom Syndrome.

Research Interests: The lab explores genomic instability, cellular sensitivity to radiation, defective DNA repair, and synthetic lethality mechanisms in cancer. Key areas include BRCA1/2 interactions, monoubiquitination of FANCD2, and development of small molecule inhibitors targeting DNA repair pathways.

Publications Trends: His work spans DNA damage response, cancer vulnerability exploitation, and repair pathway regulation, with recent studies on Polymerase Theta inhibition and CDK5-cyclin B1 in mitotic fidelity.