معرفی
Akram Alian is a researcher at the Department of Biochemistry, The Hebrew University of Jerusalem. His work bridges structural biology, biophysics, and drug discovery, with a focus on infectious pathogens, immunology, and cancer.
- PhD, The Hebrew University of Jerusalem
- Postdoctoral Fellow, University of California San Francisco
- MSc, The Hebrew University of Jerusalem
- BScAg, The Jordan University in Amman
Alian’s research centers on the structural and functional analysis of macromolecular assemblies, particularly those involved in HIV-1 replication, drug resistance, and protein design. His expertise in X-ray crystallography and Cryo-EM enables detailed exploration of enzymatic mechanisms and ligand interactions. Key areas include assay development for drug discovery and understanding allosteric regulation in enzymes like APOBEC3.
The 15 most recent publications highlight his focus on lentiviral structural adaptations (FIV/HIV), protein-RNA interactions, and cellular pathway modulation during pathogen resistance. Several articles examine HIV integrase and reverse transcriptase structures, while others explore RNA-binding proteins (translin) and enzymatic metal cofactor roles (zinc in cytidine deaminase). The 2023 study on congenital pain insensitivity mutations marks a departure into genetic disorder research.
