Adrienne Boire

Adrienne Boire, MD, PhD, is a physician-scientist at Memorial Sloan Kettering Cancer Center (MSK) and Scientific Director of the Alan and Sandra Gerry Metastasis and Tumor Ecosystems Center. She investigates leptomeningeal metastasis and its implications for understanding cancer spread to the central nervous system.

• PhD, Tufts University, Boston, MA
• MD, University of Chicago, Chicago, IL

Her research focuses on:

• Metastatic mechanisms in central nervous system cancers
• Lipid metabolism and nutrient competition in leptomeningeal tumors
• Genomic characterization of brain and spinal fluid metastases
• Immune system interactions with metastatic cancer cells
• Development of targeted therapies like intrathecal drug delivery

Analysis of 15 most recent publications reveals trends in leptomeningeal metastasis mechanisms, genomic profiling of cerebrospinal fluid, and immunotherapy applications. Subfields include chemokine signaling, tumor niche modeling, and radiation resistance mechanisms.

Scientific awards include:

• Geoffrey Beene Junior Faculty Chair (2021)
• American Academy of Neurology Neuro Oncology Investigator Award (2020)
• Pershing Square Sohn Prize (2019)
• Pew Biomedical Scholar (2018)
• Damon Runyon Clinical Investigator Award (2017)

Boire supervises graduate students and postdoctoral researchers at MSK, including those from Weill Cornell, GSK, and the Gerstner Sloan Kettering Graduate School. Her lab collaborates with multiple MSK programs including the Brain Tumor Center and Center for Experimental Therapeutics.