Adrienne Boire

Adrienne Boire is an Associate Professor at Memorial Sloan Kettering Cancer Center (MSKCC), with affiliations in the Department of Neurology, the Human Oncology and Pathogenesis Program, and the Tri-Institutional PhD Program in collaboration with Weill Cornell Medicine and Rockefeller University. She conducts her research through the Boire Lab, which focuses on the biology of leptomeningeal metastasis and the role of cerebrospinal fluid in cancer and neurologic disease.

• BA: Macalester College
• PhD: Biochemistry, Tufts University
• MD: University of Chicago Pritzker School of Medicine
• Residency: Neurology, Columbia University (Neurologic Institute)
• Fellowship: Neuro-Oncology, Memorial Sloan Kettering Cancer Center
• Postdoctoral Training: Joan Massagué Laboratory, MSKCC

Dr. Boire's research centers on the mechanisms by which cancer cells metastasize to the leptomeningeal space, survive in a nutrient-poor environment, and interact with the immune system. Her work integrates molecular oncology, neurobiology, and immunology to understand how tumors adapt to the central nervous system. Key areas include metabolic adaptation, CSF signaling, immune cell communication, and blood-brain barrier dynamics.

The recent publications highlight a strong trend in understanding tumor survival in the leptomeningeal niche, particularly through iron acquisition, complement signaling, and inflammatory responses. These studies bridge cancer biology and neuroscience, revealing how systemic diseases impact the CNS via biochemical conduits like CSF.

Dr. Boire has received significant recognition for her work:

• Elected Fellow, American Academy of Neurology (2023)
• Pershing Square Sohn Prize (2019)
• Pew Biomedical Scholar (2018)
• Damon Runyon Clinical Investigator Award (2017)

She mentors students and trainees through the Tri-Institutional PhD Program and BCMB Program, contributing to graduate education in molecular and cancer biology. While specific grants are not listed, her prestigious awards suggest strong external funding. Her lab investigates fundamental principles of metastasis, with implications for novel therapeutic strategies targeting the leptomeningeal environment.

The Boire Lab is an active research team investigating the biology of the leptomeningeal space, focusing on cancer cell dormancy, metabolic constraints, immune interactions, and inter-organ communication via CSF. The lab combines molecular biology, cell culture, and in vivo models to uncover mechanisms of disease progression.