معرفی
Dr. Aakash Basu is an Assistant Professor in Biochemistry and Royal Society University Research Fellow at Durham University's Department of Biosciences. He holds a PhD in Applied Physics from Stanford University (2013) and completed postdoctoral research at The Rockefeller University, Johns Hopkins University, and the University of Illinois. His work focuses on decoding the mechanical and structural properties of DNA/RNA, particularly how these influence biological processes like transcription, repair, and genome evolution. Key research areas include genomic methods development, protein-DNA interactions, and high-throughput assays for DNA mechanics. He leads the Basu Lab, which integrates experimental biophysics with computational tools to study DNA's mechanical code and its functional implications. Recent projects explore nucleosome stability under DNA mismatches, bacteriophage applications in plant pathogens, and sequence-dependent DNA flexibility.
- Education:
- PhD in Applied Physics, Stanford University (2013)
- Postdoctoral Positions:
- Rockefeller University (2013–2015)
- Johns Hopkins University (2015–2021)
Research interests emphasize the interplay between DNA mechanics and biological function, including how evolutionary pressures shape genome mechanics and how epigenetic modifications influence DNA dynamics. His lab employs advanced techniques like Loop-seq, single-molecule FRET, and machine learning to bridge structural and functional genomics. Awards include the Royal Society University Research Fellowship, recognizing his contributions to understanding DNA mechanics.
