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Kevin LinView profile

Assistant Professor

• Single-cell Biology
• Statistical Genetics
• Biostatistics
• +3 more

Kevin Lin is an Assistant Professor in the Department of Biostatistics at the University of Washington, joining in Fall 2023. His research focuses on developing statistical methods for analyzing single-cell data to uncover cellular mechanisms in diseases like Alzheimer’s and immune resistance. He holds a PhD from Carnegie Mellon University and completed postdoctoral training at the University of Pennsylvania. His work bridges computational methods with biological questions, emphasizing matrix factorization, network modeling, and changepoint detection. Education: PhD in Statistics & Data Science (Carnegie Mellon University, 2020) Previous Role: Postdoctoral Researcher at University of Pennsylvania (Wharton Statistics) Research interests include high-dimensional data analysis, statistical genetics, and single-cell RNA-Seq. Notable contributions include methods like Tilted-CCA for multimodal data integration and eSVD-DE for cohort-wide differential expression analysis. His work has been recognized with awards such as the Wikimedia Foundation Research Award (2023). Lin’s lab collaborates on projects involving endolysosomal dysfunction in Alzheimer’s, yeast cell division dynamics, and lineage-aware machine learning. Key achievements include over 20 publications in journals like Nature Biotechnology , PNAS , and Biometrics . He advises on grants related to single-cell technologies and serves on the EDI subcommittee for mental health initiatives at UW. Outside academia, Lin enjoys zumba and cooking.

Gloria CulverView profile

Professor

• Macromolecular assembly
• RNA-protein recognition
• Dynamics of RNA folding
• +3 more

Gloria Culver is a Professor in the Department of Biology at the University of Rochester . Her research focuses on understanding the assembly and function of the E. coli 30S ribosomal subunit, a critical component of protein synthesis. Key areas include RNA-protein recognition, dynamics of RNA folding, and identification of non-ribosomal assembly factors. Her work employs biochemical, structural, and genetic approaches to elucidate the molecular mechanisms governing ribosome biogenesis. Dr. Culver holds a PhD and has conducted extensive studies on ribosomal protein functions, RNA maturation, and assembly pathways. Her lab uses in vitro reconstitution systems and genetic screens to investigate how ribosomal proteins and RNA interact to form functional complexes. Notable techniques include chemical probing of RNA and affinity chromatography to identify assembly intermediates. Research highlights: RNA folding dynamics, ribosomal protein roles in assembly, and discovery of novel assembly factors. Lab contributions: Pioneering methods to study ribosome biogenesis and translational fidelity. Her findings contribute to broader understanding of ribonucleoprotein (RNP) assembly and have implications for antimicrobial drug development.

Elaine SiaView profile

Professor

• Molecular Biology
• Genetics
• Mitochondrial DNA
• +3 more

Elaine Sia leads a research laboratory focused on understanding the replication, repair, and maintenance of mitochondrial DNA (mtDNA) in the budding yeast Saccharomyces cerevisiae . Her work emphasizes the unique requirements of this organelle's genome, leveraging genetic and molecular techniques to identify proteins involved in mtDNA stability. Key research areas include mitochondrial mutagenesis mechanisms, roles of mismatch repair homologs like Msh1p, and interactions between nuclear and mitochondrial DNA repair pathways. Her lab employs yeast as a model due to its tractability for genetic manipulation and relevance to human mitochondrial diseases. Major projects involve analyzing proteins such as Mip1p (Pol γ), Msh1p, and Mgm101p, using genetic reporters to quantify mutation rates and recombination events. They also screen for novel mitochondrial proteome components, contributing to the understanding of mitochondrial dysfunction's role in cellular pathology. Recent work highlights nuclear proteins' impact on mitochondrial DNA stability, including nonhomologous end-joining factors and FEN1's role in mtDNA integrity. Publications span topics like ATM signaling in mitochondrial contexts and structural studies of rRNA methyltransferases, reflecting interdisciplinary approaches to mitochondrial biology. Awards and grants are not specified in the provided text, though her extensive publication record indicates sustained research impact. Advising details are implicit through co-authorship but lack explicit student-mentor relationships in the text. The lab's future directions likely involve advancing mitochondrial medicine through mechanistic insights into mtDNA maintenance and its implications for human disease.

David AmaralView profile

Professor

• Autism Spectrum Disorder
• Developmental Neuroscience
• Amygdala Function
• +2 more

David Amaral is Professor of Psychology and Behavioral Sciences at UC Davis, specializing in neurodevelopmental disorders research. His laboratory investigates neural mechanisms underlying autism spectrum disorder (ASD), with particular focus on amygdala development, neuroinflammation pathways, and early biomarkers. Amaral's work integrates neuroimaging, primate models, and clinical studies to identify structural brain alterations in ASD. Recent projects examine how maternal immune activation influences fetal brain development and subsequent behavioral outcomes. He directs research initiatives examining longitudinal trajectories of brain development in autistic children and leads tissue banking efforts through Autism BrainNet. Amaral's work has contributed to understanding atypical neurodevelopment across diagnostic subgroups.

Nicola CookView profile

Researcher

• Genomics
• Sex Allocation
• Parasitoid Wasps
• +3 more

Dr Nicola Cook is a Researcher and Managing Editor/Publicity Officer at the School of Biology, University of St Andrews. She is affiliated with the Centre for Biological Diversity and actively contributes to research in genomics, sex allocation mechanisms, and parasitoid wasp biology. Her work spans evolutionary biology, molecular biology, and educational outreach through initiatives like the 4273pi bioinformatics project. Her research focuses on understanding genomic and epigenetic influences on sex allocation in parasitoid wasps, particularly Nasonia vitripennis. She also explores the effects of environmental factors, such as neonicotinoids, on insect behavior. Collaborations with institutions globally highlight her role in interdisciplinary projects, including studies on cold adaptation in flies and barley epigenetics. Dr Cook has published extensively in journals like PLoS Computational Biology and BMC Genomics , with a strong emphasis on experimental and computational approaches. She has been involved in grants such as the NERC-funded 'Identifying the genetic targets of sexual selection.' Her outreach activities include organizing bioinformatics workshops for schools, promoting STEM education.

Michael KrützenView profile

Professor

• Evolutionary Biology
• Genetics
• Animal Behavior
• +5 more

Michael Krützen is a Professor and Director of the Institute of Evolutionary Anthropology (IEA) at the University of Zurich. His research focuses on the social evolution of primates and cetaceans, particularly male cooperation strategies, genetic relationships, and cultural transmission. He leads the Evolutionary Genetics Group, employing genomic and ecological tools to study population dynamics, conservation genomics, and adaptive evolution in species like orangutans and dolphins. Key projects include analyzing genetic signatures of adaptation in marine and primate populations, reconstructing demographic histories, and investigating the role of culture in social evolution. His work integrates field studies, molecular genetics, and computational modeling to address questions about social behavior, reproductive success, and evolutionary processes. Notable contributions include uncovering complex male alliance systems in dolphins and identifying genetic markers for conservation efforts in endangered species. Krützen collaborates internationally, publishing extensively on topics such as dolphin vocal communication, tool use, and the genetic basis of social structures.

Christopher J ShoemakerView profile

Assistant Professor

• Autophagy Mechanisms
• Cellular Degradation Pathways
• Selective Autophagy
• +1 more

Christopher J. Shoemaker is Assistant Professor of Biochemistry and Cell Biology at Dartmouth's Geisel School of Medicine, leading research on autophagy mechanisms. His laboratory investigates how cells eliminate toxic structures through degradation pathways, with implications for neurodegeneration, cancer, and aging. Current projects examine selective autophagy targeting, non-canonical degradation routes, and biochemical reconstitution of autophagy machinery. Shoemaker's work combines cellular and biochemical approaches to study autophagy at molecular resolution. Recent publications focus on receptor-mediated autophagy initiation, ER-phagy mechanisms during nutrient stress, and mitophagy regulation. His team utilizes CRISPR screening to identify novel autophagy factors and employs biochemical reconstitution to define fundamental mechanisms. Laboratory members include graduate students Brian North, Sam Liu, Carter Tracy, and Adwaita Bose. The lab operates within Dartmouth's Vail Building and maintains collaborative relationships internationally. No specific grants or scientific awards are detailed in the source materials.

• Bayesian Statistics
• Biostatistics
• Mixture Models
• +6 more

Mahlet G. Tadesse is a Professor and Chair of the Department of Mathematics & Statistics at Georgetown University. She previously held an Assistant Professor position at the University of Pennsylvania. She earned her Ph.D. and M.Sc. in Biostatistics from Harvard University and a B.S. in Mathematics from the University of the District of Columbia. Her research focuses on developing statistical and computational tools for analyzing genomic data, with emphasis on Bayesian methods, variable selection, and integrative approaches to genomic data analysis. Her expertise spans Bayesian statistics, biostatistics, mixture models, and omics-based bioinformatics. She investigates high-dimensional datasets to identify biological markers, predict clinical outcomes, and integrate biological knowledge into genomic studies. Current projects include biomarker discovery for hepatocellular carcinoma, analysis of maternal-fetal genetic interactions, and modeling species dynamics in biodiversity-rich ecosystems. Dr. Tadesse has published extensively on topics such as Bayesian variable selection, integrative genomics, and computational methods in proteomics and metabolomics. Her work bridges statistical theory and application, addressing challenges in precision medicine, cancer biology, and ecological dynamics. Scientific Awards: Elected Member of the International Statistical Institute (2006), Fellow of the American Statistical Association (2013) Her contributions include advancing alignment methods for LC-MS data, developing hierarchical models for multi-omics integration, and exploring racial disparities in cancer outcomes. She leads Georgetown’s Mathematics & Statistics Department, fostering interdisciplinary research and education in data science.

David G. SchatzView profile

Professor

• Antibody Diversity
• Gene Rearrangement (B-Lymphocyte/T-Lymphocyte)
• Somatic Hypermutation
• +5 more

Dr. David G. Schatz is the Waldemar Von Zedtwitz Professor of Immunobiology and Professor of Molecular Biophysics and Biochemistry at Yale University, serving as Chair of the Department of Immunobiology. His research focuses on mechanisms of antigen receptor gene assembly and diversification in the immune system, including V(D)J recombination and somatic hypermutation. He has co-authored over 180 articles in top journals and received prestigious awards like the Paul Ehrlich Prize and National Academy memberships. Schatz holds B.S. and M.S. degrees from Yale (1980), an M.A. from Oxford (1982), and a Ph.D. from MIT (1990), followed by postdoctoral work at the Whitehead Institute. Education: B.S./M.S. Yale (1980), M.A. Oxford (1982), Ph.D. MIT (1990). Professional roles include Co-Editor of Immunity, NIH study section leadership, and graduate education leadership. Research interests span RAG protein evolution, transposon domestication, and mechanisms of somatic hypermutation targeting. Key achievements include discovery of RAG1/RAG2 proteins, elucidating transposase origins of adaptive immunity, and identifying critical regulators of genomic stability in lymphocytes. Collaborators include leading immunologists and structural biologists, with frequent publications on immune diversity mechanisms. Recognition includes election to the National Academy of Sciences (2018) and National Academy of Medicine (2019), as well as AAAS Fellowship and international prizes. His lab's work bridges basic science and translational insights into immune dysfunction and cancer.

Jennetta W. HammondView profile

Assistant Professor

• Neuroimmunology
• Neurology
• Neuroscience
• +5 more

Dr. Jennetta W. Hammond is an Assistant Professor in the Department of Neurology, Neuroimmunology and holds a joint appointment in the Department of Neuroscience at the University of Rochester School of Medicine and Dentistry. Her research focuses on neuroimmune mechanisms in neurological disorders, particularly investigating the Sez6 gene family and their roles in neuroprotection through complement regulation. She also explores mitochondrial stress pathways linked to movement disorders and autoimmune mechanisms in cerebellar ataxia. Education: PhD in Cell and Developmental Biology from the University of Michigan (2008) BS in Zoology from Brigham Young University (2002) Research Interests: Complement system regulation in neurodegeneration Autoantibody-mediated cerebellar ataxia Mitochondrial dysfunction in movement disorders Animal model development for neuroimmune diseases Her lab has identified the Sez6 gene family as critical regulators of synaptic preservation during development and disease states like Alzheimer’s and multiple sclerosis. Current projects include studying Sez6L2 autoantibodies in autoimmune ataxia and characterizing the Mix23 gene’s role in mitochondrial stress. Publications: Dr. Hammond has authored 17 journal articles focusing on neuroimmunology, complement biology, and molecular motor mechanisms. Recent work highlights synaptic protection strategies and novel therapeutic targets for neurodegenerative diseases. Labs & Teams: Her research is conducted within the Center for Neurotherapeutics Discovery at the University of Rochester Medical Center, collaborating extensively on translational neuroscience projects.

Luis A. PardoView profile

Professor

• Molecular Biology
• Cancer Biology
• Ion Channel Physiology
• +3 more

Prof. Luis A. Pardo is a Professor at the University Medical Center Göttingen and Group Leader at the Max Planck Institute for Multidisciplinary Sciences. His research focuses on ion channels' roles in cancer progression and tumor biology. He holds an MD from the University of Oviedo (1986) and a Ph.D. (1990), followed by postdoctoral training at the Max Planck Institute of Biophysical Chemistry (1991-1993). He has led research groups since 2004, advancing therapeutic strategies targeting ion channels like Kv10.1. Research interests include: molecular mechanisms of ion channels, tumor-specific ion channel expression, and development of diagnostic/therapeutic tools. His work bridges electrophysiology, microscopy, and animal models to study tumor cell behavior and cytoskeletal dynamics. Key contributions include identifying Kv10.1's tumor-specific expression and its role in cell division, primary cilium regulation, and drug repurposing for cancer treatment. The group's lab, Oncophysiology, explores channel function, molecular mechanisms, and translational applications in oncology.

Paul Andrew JohnstonView profile

Professor

• Drug Discovery
• Cancer Research
• High Content Imaging
• +5 more

Paul Andrew Johnston is a Professor of Pharmaceutical Sciences at the University of Pittsburgh School of Pharmacy. He holds a B.Sc. (Honors) and Ph.D. in Biochemistry from the University of East Anglia, followed by postdoctoral research at UNC Chapel Hill, Duke University, and the Howard Hughes Medical Institute. With over 30 years of drug discovery experience across academia and industry, his expertise spans high content imaging, HTS/HCS assay development, and 3D tumor modeling. He founded the University of Pittsburgh Molecular Library Screening Center (PMLSC), leading 21 HTS campaigns and pioneering the ALMANAC database for cancer drug combinations. His current research focuses on prostate cancer, melanoma, head/neck cancer, and hepatocellular carcinoma drug discovery through innovative screening approaches. Education: B.Sc. with Honors (2.1), Biochemistry, University of East Anglia (1978) Ph.D., Biochemistry, University of East Anglia (1983) Research Focus: Integrating advanced imaging technologies with high-throughput screening to identify synergistic drug combinations and novel therapeutics. Specializes in patient-derived 3D tumor models, androgen receptor inhibition in prostate cancer, and overcoming drug resistance mechanisms. Active in developing standardized HTS protocols for precision medicine applications. Key Contributions: Developed NCI-60 cell line combination screening methodologies, pioneered multicellular tumor spheroid analysis frameworks, and established organoid models for personalized cancer therapy evaluation. Served as past president of the Society for Biomolecular Imaging and Informatics (SBI2). Advising & Grants: Mentors Pharm.D. and Ph.D. students in drug discovery. Leads collaborative projects with academic and industry partners, including work on HDAC8 inhibitors for kidney injury and Src kinase modulators. Actively participates in grant initiatives related to cancer drug discovery and assay development. Labs & Facilities: Director of chemical biology laboratories within the School of Pharmacy's Pharmaceutical Sciences department. Oversees the PMLSC's HTS/HCS facilities and maintains close ties with the University of Pittsburgh Liver Research Center for collaborative oncology studies.

Sofie Amalie RinggaardView profile

Assistant Professor

• Credit Risk Management
• Banking
• Risk Management
• +4 more

Sofie Amalie Ringgaard is a Tenure Track Assistant Professor at Aalborg University Business School (Faculty of Social Sciences and Humanities), affiliated with the Accounting Research Group. Her work focuses on credit risk management, banking systems, and management control in financial sectors. She holds an ORCID identifier (0000-0001-9055-7766) and has been affiliated with École des Hautes Études Commerciales (2022–2023) as a visiting researcher. Research interests include risk management frameworks in banks, boundary systems analysis, and the interplay between budgeting and forecasting. Recent work examines Anti-Money Laundering (AML) compliance and evolving budgetary models in finance sectors. She has published in journals like Journal of Management Control and presented at academic conferences. Current projects include 'Valuation Studies of Management Control in the Insurance Sector' (2024–2027) and 'New Management and Budget Models in the Financial Sector' (2020–2026). Her work bridges accounting theory with practical financial governance challenges.

Lydia C PowellView profile

Lecturer

• Bacterial Biofilms
• Antimicrobial Resistance
• Antibiofilm Therapeutics
• +6 more

Dr. Lydia C Powell is a Lecturer in Microbiology and Infectious Diseases at Swansea University School of Medicine. Her research bridges engineering and biomedical sciences, focusing on bacterial cell mechanics, biofilm dynamics, and translational therapies for cystic fibrosis and chronic infections. Key contributions include developing anti-biofilm therapeutics now in clinical trials (AlgiPharma AS/Qbiotics) and investigating AMR mechanisms in biofilms to identify novel treatment targets. Affiliations: School of Medicine, Microbiology and Infectious Diseases Group Research interests include: Bacterial biofilm biophysics Antimicrobial resistance dynamics Alginate-based therapies Host-pathogen interactions Medical device biofilm prevention Recent work highlights: 2025: Ovarian cancer resistance mechanisms and metastasis 2023: Alginate oligosaccharide drug design against Pseudomonas 2022: Epoxy-tigliane wound healing agents Collaborations with industry (AlgiPharma AS/Qbiotics) and academia (e.g., Prof Thomas Wilkinson) advance clinical translation of findings.

• Population Genetics
• Human Evolution
• Ancient DNA Analysis
• +4 more

Per Sjödin is a researcher at Uppsala University's Department of Organismal Biology, specializing in population genetics and human evolutionary studies. Holding a PhD and Docent (equivalent to Associate Professor) qualification, he maintains active research collaborations across multiple international institutions. His educational background includes a PhD and Docent qualification from Uppsala University, establishing his expertise in genetic analysis and evolutionary biology. Sjödin's research focuses on population genetics , human evolutionary history , and ancient DNA analysis , with particular emphasis on African populations and human migrations. His work integrates genomic data with anthropological findings to reconstruct demographic histories and identify genetic adaptations. He employs advanced computational methods to analyze population structure, admixture events, and evolutionary timelines across diverse human groups. Analysis of Sjödin's recent publications reveals consistent focus on human population history , particularly regarding African genomic diversity and ancient human migrations . His work frequently addresses methodological challenges in genomic analysis while contributing substantive findings about human evolutionary timelines and population relationships. The research demonstrates strong interdisciplinary connections between genetics, anthropology, and computational biology. Sjödin actively collaborates with major research groups studying human evolution, particularly focusing on underrepresented populations. His work appears in high-impact journals including Science, Nature, and PNAS, reflecting significant contributions to understanding human demographic history and genetic diversity. His laboratory work centers on genomic analysis of population history, with particular emphasis on African populations and ancient DNA. Sjödin contributes to major collaborative projects investigating human migrations, population divergences, and adaptive evolution across diverse human groups.