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Nicolas DemaurexView profile

Professor

• Cell Physiology
• Signal Transduction
• Ion Channels
• +5 more

Nicolas Demaurex is a Full Professor in the Department of Cell Physiology and Metabolism at the University of Geneva's Faculty of Medicine, where he also serves as Vice-dean since 2012. His academic journey began with medical studies at the University of Geneva (1982-1989), followed by dual doctorates in Medicine and Biological Sciences in 1993, and Privat-Docent qualification in 2001. His research focuses on cellular mechanisms of signal transduction, particularly calcium signaling, ion channels, and oxidative stress. His laboratory investigates how mitochondria regulate calcium signaling, the function of proton channels in immune cells, and the physiological implications of these processes for cellular homeostasis and immune responses. His work bridges fundamental cell biology with physiological applications, revealing novel mechanisms in phagocytosis, mitochondrial dynamics, and organelle communication. Demaurex's publication record demonstrates consistent high-impact contributions, with articles appearing in Science, EMBO Journal, Journal of Experimental Medicine, and other leading journals. His research has been recognized with multiple recommendations from the Faculty of 1000, highlighting its significance in the field. Award from the Swiss Society of Infectious Diseases (1993) Career award from the Max Cloëtta Foundation, Zürich (1997) Research Award from the Leenaards Foundation, Lausanne (1999) Elected vice-president of the Swiss Society of Physiology (2012) As an educator, Demaurex has mentored numerous PhD students to completion and has been actively involved in medical education since 1997. His research program has been consistently supported by substantial grants from the Swiss National Science Foundation, with projects totaling over 2.5 million Swiss Francs since 1996. His laboratory has evolved into a collaborative team including post-doctoral fellows, PhD students, and technical staff focused on cutting-edge cellular physiology research. Demaurex leads the Bioimaging Core Facility at the University of Geneva Medical School and serves on the Federal Committee for Medical Professions (MEBEKO), demonstrating his significant contributions to both research infrastructure and academic governance.

Dane CrossleyView profile

Professor

• Developmental Physiology
• Cardiovascular Biology
• Comparative Zoology
• +2 more

Dane Crossley is a Professor of Physiology and Graduate Coordinator in the Department of Biological Sciences at the University of North Texas. His lab investigates integrative developmental physiology with emphasis on cardiorespiratory systems in vertebrates. Research spans fetal programming, cardiovascular development, and environmental adaptations. Primary research areas include hypoxic effects on alligator development, cardiac anoxia tolerance in turtles, and evolutionary physiology. Recent work explores mitochondrial function, thermal remodeling, and chemoreflex plasticity. Laboratory focus: Integrative developmental cardiorespiratory physiology Comparative animal physiology Fetal programming in vertebrates Cardiovascular development

Kay OhlendieckView profile

Professor

• Proteomics
• Muscular Dystrophy
• Aging Biology
• +3 more

Professor Kay Ohlendieck holds the position of Professor and Chair of the Department of Biology at the National University of Ireland, Maynooth, within the Faculty of Science & Engineering. His academic journey includes a Diplom in Biology (M.Sc.) from the University of Konstanz (1980-1985) and a Ph.D. in Biochemistry from University College Cork (1985-1989). He has held various roles, including postdoctoral fellowships at the University of Iowa and State University of New York, before transitioning to academic positions at University College Dublin and his current role since 2002. In 2011, he was awarded a D.Sc. for his published work. His research focuses on proteomic analysis of skeletal muscle, particularly in aging and dystrophic conditions. Key areas include calcium handling, membrane proteins, and the pathophysiology of muscular dystrophy. His work employs advanced techniques like two-dimensional gel electrophoresis and proteomic profiling to identify biomarkers and understand disease mechanisms. Education: Diplom in Biology (M.Sc.), University of Konstanz, Germany Ph.D. in Biochemistry, University College Cork D.Sc. (2011), National University of Ireland Recent publications highlight his work on muscular dystrophy biomarkers, aging skeletal muscle proteomics, and calcium-regulated proteins in muscle disorders. His research spans from basic biochemical analysis to clinical applications, emphasizing translational outcomes. Collaborations include studies on diabetic muscle weakness and the role of chaperones in muscle pathology. Labs and affiliations include the Human Health Institute, where he leads proteomic initiatives to address muscle-related diseases. His work bridges biochemistry, molecular biology, and clinical science to advance understanding of muscle disorders and aging processes.

Donald MauriceView profile

Professor

• Cardiology and circulatory sciences
• Vascular and endothelial biology
• Atherosclerosis
• +3 more

Donald Maurice is a Professor in the Department of Biomedical and Molecular Sciences at Queen's University, with cross-appointments at the Translational Institute of Medicine (TIME). His research focuses on cyclic nucleotide signaling pathways, particularly the role of phosphodiesterases (PDEs) in cardiovascular diseases such as atherosclerosis and angiogenesis. He leads the Maurice Lab, investigating how cAMP and cGMP compartmentation regulates vascular cell functions. Education includes a BSc in Biochemistry (Carleton University, 1985), MSc and PhD in Pharmacology (McMaster University, 1990), and postdoctoral training at the University of North Carolina at Chapel Hill (1993). Research emphasizes PDEs' spatial regulation in human vascular cells, aiming to develop therapies targeting compartment-specific signaling. His work highlights PDEs' potential in treating maladaptive cardiovascular processes. Key findings include PDE5's role in platelet function compartmentation and PDE4D's regulation of vascular permeability. Collaborations span translational medicine and drug discovery, with ongoing studies on PDE inhibitors' therapeutic applications.

James E. BruceView profile

Adjunct Professor

• Proteomics
• Mass Spectrometry
• Protein Interactions
• +5 more

James E. Bruce is an Adjunct Professor in the Department of Chemistry at the University of Washington, College of Arts & Sciences. He leads the Bruce Lab, focusing on advanced mass spectrometry and proteomics to study protein interactions, structural biology, and mitochondrial function. His research develops cutting-edge technologies such as cross-linking mass spectrometry (XL-MS) and Protein Interaction Reporter (PIR) cross-linkers to analyze protein networks in living systems. Key areas include understanding cancer drug resistance, bacterial infections, and mitochondrial dysfunction. The lab also pioneered tools like XLinkDB 2.0 for large-scale structural analysis. Research interests span proteomics, mass spectrometry instrumentation, and systems biology. Bruce’s work addresses challenges in quantifying protein interactions in cancer cells and bacterial pathogens, with applications in drug discovery and disease mechanisms. His lab collaborates across disciplines, including with the Singh Lab (bacterial infections) and Tian Lab (mitochondrial biology). Publications highlight innovations in cross-linking techniques, interactome dynamics, and structural biology. The lab’s tools and methodologies are widely adopted for studying protein complexes and conformational changes in health and disease.

Christopher M. LoughreyView profile

Professor

• Cardiac Pathophysiology
• Heart Failure
• Myocardial Infarction
• +3 more

Professor Christopher M. Loughrey is Professor of Experimental Cardiology and Head of the School of Biodiversity, One Health and Veterinary Medicine at the University of Glasgow. He directs research at the Glasgow Cardiovascular Research Centre, focusing on molecular mechanisms of heart failure using integrative approaches spanning single-cell physiology to whole-animal models. His research program investigates: Calcium handling in cardiomyocytes Adverse cardiac remodeling pathways Therapeutic targeting of transcription factors Ischemia-reperfusion injury mechanisms Novel pharmacological interventions Research trends from recent publications reveal a focus on RUNX transcription factors as therapeutic targets, metabolic therapies for heart failure, and innovative calcium-modulating drugs. Significant honors include: Fellowship in the Royal Society of Biology Elected Fellowship of the Royal College of Veterinary Surgeons British Cardiac Society Judge's Prize President's Prize from Association of Veterinary Teachers He leads a British Heart Foundation Programme Grant investigating cardiac remodeling and mentors doctoral candidates in cardiovascular pathophysiology. His laboratory develops advanced murine models of myocardial infarction and heart failure for therapeutic discovery.

Amy HannaView profile

Research Fellow

• Cardiovascular Disease
• Muscle Physiology
• Ion Channel Biology
• +3 more

Dr. Amy Hanna is a Postdoctoral Research Fellow at the Institute for Molecular Bioscience (IMB), focusing on molecular mechanisms underlying cardiovascular and muscle disorders. Her research integrates biochemistry, genetics, and metabolomics to investigate diseases such as dilated cardiomyopathy, malignant hyperthermia, and skeletal muscle channelopathies. Key research areas include calcium signaling pathways, ion channel dysfunction, and the role of genetic mutations in disease pathology. She employs rodent models, metabolomics profiling, and advanced imaging techniques like MyoSight for skeletal muscle analysis. Her recent work explores therapeutic interventions targeting RyR1/RyR2 channels and TRPV1 variants, alongside the effects of chemotherapeutic agents (e.g., doxorubicin) on cardiac function. Collaborations involve molecular modeling and drug development initiatives.

Holly ShielsView profile

Professor

• Environmental Physiology
• Cardiac Physiology
• Thermal Biology
• +3 more

Holly Shiels is a Professor in the Division of Cardiovascular Sciences at the University of Manchester. Her research focuses on Integrative and Environmental Physiology, exploring how environmental changes impact cardiac function across species. She has held academic positions since 2004, progressing from Lecturer to Professor. Shiels is an Honorary President of the Fisheries Society of the British Isles and serves as a Fellow of The Physiological Society and Royal Society of Biology. Her work addresses pollution, thermal biology, and cardiovascular health in animals and humans, with implications for UN Sustainable Development Goals. She has received awards including the 2016 Making a Difference Award and Teaching Excellence Award. Her research spans over 146 publications, with recent studies on microplastic bioaccumulation in sea turtles and cardiac effects of environmental pollutants. She leads projects funded by the British Heart Foundation and collaborates internationally on environmental and health impacts of pollution.

Rowena LaveryView profile

Senior Lecturer

• Reproductive Biology
• Molecular Genetics
• Sex Determination
• +9 more

Rowena Lavery is a Senior Lecturer in Biotechnology at Flinders University, College of Medicine and Public Health. She holds a PhD from the University of Galway and has extensive international research experience in reproductive biology and molecular genetics across institutions in Ireland, Italy, France, and Australia. She transitioned into education in 2016, teaching across higher and vocational education programs at Holmesglen, RMIT, and Flinders University. Doctor of Philosophy (PhD), University of Galway Bachelor of Science (Hons) 1st Class, University of Galway National Diploma in Fine Chemicals and Pharmaceuticals, Galway-Mayo Institute of Technology Certificate IV in Training and Assessment (TAE40110) Her research focuses on reproductive biology , particularly the molecular mechanisms of SOX9 and RSPO1 in sex determination and gonadal development. She pioneered work showing that female sex differentiation is actively induced by RSPO1 , overturning the default pathway dogma. Her later work revealed SOX9 ’s role in RNA splicing, expanding its known functions beyond transcription. She combines this deep scientific background with innovative teaching approaches, emphasizing work-integrated learning (WIL), gamification, and cloud-based platforms like Canvas with H5P tools to create dynamic, student-centered experiences. The analysis of her publications reveals a consistent trajectory in developmental genetics and reproductive biology , with recent contributions shifting toward educational research and pedagogical innovation. Her work spans molecular diagnostics, stem cell research, and clinical applications, with a strong emphasis on both basic science and translational outcomes. Her scientific and teaching excellence has been recognized through numerous awards, including: RMIT SEH Top Course Award (multiple years, across Biochemistry, Histology, and Molecular Biology) Harold–Mitchell Postdoctoral Travel Grant Equity Trustees Equipment Grant Faculty of 1000 Recommendations for high-impact research National University of Ireland PhD Scholarship Rowena Lavery has supervised and mentored numerous students across multiple programs, though specific names are not listed. She has secured competitive grants for laboratory equipment and research, demonstrating strong project leadership. Her professional engagement includes extensive participation in workshops and industry collaborations with Helena Laboratories, Thermo Scientific, Peter MacCallum Cancer Centre, and Monash Medical Centre, ensuring her teaching remains aligned with real-world applications. She is a member of the Australian and American Societies for Biochemistry and Molecular Biology, and her work contributes to UN Sustainable Development Goals in health and education.

• Computational Neuroscience
• Mathematical Biology
• Biophysics
• +3 more

Dr. Leiv Øyehaug is an Associate Professor at the Department of Computer Science, Faculty of Technology, Art and Design, Oslo Metropolitan University. His research focuses on computational modeling of biological systems through interdisciplinary approaches combining mathematics and physiology. Neuroglial interactions and ion dynamics Cardiomyocyte calcium handling mechanisms Mathematical modeling of skin pigmentation processes Systems biology approaches to complex physiological phenomena Øyehaug's work spans multiple disciplines with key contributions in neuronal activity modeling, cardiac calcium signaling, and dermal system analysis. He collaborates extensively with physiological research groups while maintaining mathematical rigor in his models. The publications demonstrate a strong focus on using quantitative approaches to understand pathophysiological mechanisms in both neural and cardiac contexts.

• Cardiac Physiology
• Vascular Biology
• Autonomic Nervous System
• +3 more

Nathan Grainger serves as a Research Assistant Professor in the Department of Physiology and Cell Biology at the University of Nevada, Reno, where his laboratory investigates fundamental mechanisms of pacemaker function in cardiac and urinary systems. His academic credentials include a B.Sc. in Neuroscience from the University of Manchester, United Kingdom, and a Ph.D. in Cellular and Molecular Pharmacology and Physiology from the University of Nevada, Reno. Dr. Grainger's primary research explores the autonomic regulation of sinoatrial node vasculature, energy metabolism in pacemaker cells, and pathophysiological mechanisms in heart failure. His work bridges cardiac electrophysiology and vascular biology, with significant focus on microvascular rarefaction, mitochondrial-sarcoplasmic reticulum interactions, and regional heterogeneity in nodal tissue. Additionally, he investigates peristaltic pacemaker mechanisms in the renal pelvis, examining ion channel dynamics and interstitial cell function. Analysis of his 15 most recent publications reveals a cohesive research trajectory centered on pacemaker dysfunction across organ systems. His cardiac studies predominantly address sinoatrial node vulnerability in heart failure (including HFpEF), while urological work emphasizes Ca 2+ -activated chloride channels and T-type calcium channels in urinary tract pacemaking. This dual focus demonstrates how cellular energy regulation and vascular control mechanisms underlie rhythmicity in both heart and urinary systems. Dr. Grainger leads an active research laboratory utilizing advanced techniques including vibratome sectioning for live imaging of intact pacemaker regions, molecular channel analysis, and metabolic studies. His team develops innovative approaches to isolate and characterize pacemaker tissues while investigating translational implications for heart failure and urinary motility disorders.

• Physiology
• Calcium Signaling
• Microcirculation
• +5 more

Guiling Zhao is an Assistant Professor in the Department of Pharmacology & Physiology at the University of Maryland School of Medicine. Her research focuses on calcium signaling , microcirculation , and electro-metabolic signaling in cardiovascular regulation. Primary Appointment: Pharmacology & Physiology, University of Maryland School of Medicine Email: gzhao@som.umaryland.edu Dr. Zhao earned her PhD in Pathophysiology from Southern Medical University, China, and completed postdoctoral training in Physiology at the University of Tennessee Health Science Center. Her work explores how Ca²⁺ signaling proteins and ion channels control vascular and cardiac function, with a current emphasis on coronary blood flow via the Z-Prep ex vivo model. Her 15 most recent publications highlight pericyte-mediated blood flow regulation , K ATP channel dynamics , and mitochondrial permeability mechanisms . These studies span disciplines like Physiology , Cardiovascular Biology , and Imaging Technology , with subfields addressing microcirculation , vascular hyporeactivity , and electro-metabolic coupling . Scientific recognition includes Editorial highlights in Science and PNAS Commentary in PNAS by Grainger and Santana Journal Club features in Journal of General Physiology

Rachelle Crosbie-WatsonView profile

Professor

• Muscular Dystrophy Research
• Neurology
• Cell Biology
• +3 more

Rachelle Crosbie-Watson is a Professor in the Department of Integrative Biology & Physiology at the University of California, Los Angeles (UCLA), with dual appointments in Neurology and the Brain Research Institute. She serves as Education Liaison for the Center for Duchenne Muscular Dystrophy and holds memberships in multiple graduate programs including Biochemistry, Biophysics & Structural Biology; Cell & Developmental Biology; JCCC Cancer and Stem Cell Biology; and Molecular, Cellular & Integrative Physiology. Her research pioneers sarcospan's role within the dystrophin-glycoprotein complex, demonstrating that sarcospan introduction ameliorates muscular dystrophy in mouse models. The Crosbie lab developed exclusive molecular tools for sarcospan study and collaborates with the Baum lab on high-throughput screening assays targeting sarcospan expression for Duchenne Muscular Dystrophy therapy. She also partners with the Spencer group to engineer novel mouse models of muscle disease, advancing mechanistic understanding of muscular pathologies. Analysis of her 2007-2013 publications reveals consistent focus on sarcospan therapeutic applications, dystrophin-glycoprotein complex stabilization, and Akt signaling pathways in muscle regeneration. Key trends include leveraging mouse models for disease mechanism studies, exploring glycosylation's role in sarcolemmal integrity, and investigating ciliary motility genetics through collaborative networks. Nominated for UCLA's Teaching Distinction Award, Dr. Crosbie-Watson directs the Beckman Undergraduate Scholars Program and has trained numerous HHMI, Beckman, and Dean's scholars. She successfully mentored a Marshall Scholarship recipient—one of only thirteen UCLA students ever awarded this prestigious fellowship—demonstrating exceptional commitment to developing future scientific leaders. The Crosbie lab maintains strategic collaborations including the Baum lab for therapeutic development and the Spencer group for muscle disease modeling, driving innovation in muscular dystrophy research through integrated approaches spanning molecular tools, high-throughput screening, and translational physiology.

Benjamin L. ProsserView profile

Associate Professor

• Physiology
• Muscle Biology
• Neurodevelopmental Disorders
• +5 more

Benjamin L. Prosser is an Associate Professor of Physiology at the Perelman School of Medicine, University of Pennsylvania , where he serves as Associate Director of the Pennsylvania Muscle Institute and Director of the Center for Epilepsy and NeuroDevelopmental Disorders (ENDD). His research bridges cardiovascular mechanobiology and neurodevelopmental disorders , focusing on microtubule dynamics in heart failure and antisense oligonucleotide therapies for STXBP1/SYNGAP1-related epilepsy. Ph.D. in Molecular Medicine, University of Maryland School of Medicine (2009) B.S. in Health and Exercise Science, Wake Forest University (2005) His cardiovascular research explores how microtubules regulate cardiomyocyte mechanics, nuclear integrity, and myocardial stiffness in diseases like LMNA cardiomyopathy and heart failure with preserved ejection fraction. Key findings include the role of tubulin tyrosination in cardiac function and the development of anti-microtubule therapeutics. In neurodevelopmental disorders , Prosser collaborates with patient advocacy groups to model and treat STXBP1 and SYNGAP1 mutations, leveraging his daughter's diagnosis to drive translational efforts. His lab integrates data from 534 STXBP1 cases to define clinical signatures. The 15 most recent articles (2025-2022) highlight dual expertise in cardiac mechanotransduction and neurogenetics, with a focus on microtubules, antisense oligonucleotides, and stress response pathways. Labs & Collaborations include the Prosser Lab , the Center for Epilepsy and NeuroDevelopmental Disorders, and partnerships with Ionis Pharmaceuticals for RNA-targeted therapies.

Bradley PalmerView profile

Assistant Professor

• Cardiac muscle physiology
• Calcium regulation in heart function
• Zinc's role in cardioprotection
• +4 more

Bradley Palmer is an Assistant Professor in the Department of Molecular Physiology and Biophysics at the University of Vermont's Robert Larner, M.D. College of Medicine. With a Ph.D. in Bioengineering from Pennsylvania State University and postdoctoral training at UVM, Dr. Palmer has led cardiac muscle research since 2009 through techniques spanning intracellular ion detection, patient biopsy analysis, and comparative studies across insect and human cardiac systems. Key research focus on zinc-calcium interactions in cardioprotection Investigates diastolic dysfunction mechanisms and myofilament regulation Collaborates with Dr. Stefan Vogt at Argonne National Laboratories for zinc distribution mapping in cardiac cells His work demonstrates how intracellular zinc modulates calcium handling through sarcoplasmic reticulum load reduction and sodium-dependent calcium efflux enhancement. The lab's publications cover cardiac cross-bridge dynamics, erythropoietin's inotropic effects, and myosin-binding protein C's structural roles. Lab Members: Ting, Yuan Wang Techniques Used: Simultaneous Zn 2+ /Ca 2+ detection, viscoelastic modeling, clinical biopsy analysis