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Henri TiedgeView profile

Professor

• RNA Biology
• Neurobiology
• Translational Regulation
• +5 more

Henri Tiedge, PhD , is a Professor at the Department of Physiology and Pharmacology within SUNY Downstate Medical Center . His research focuses on regulatory brain cytoplasmic (BC) RNAs , particularly their role in translational control mechanisms at neuronal synapses and their implications in neurological disorders and tumor biology . Institutional Affiliation: SUNY Downstate Medical Center (College of Medicine, Physiology and Pharmacology) Academic Rank: Professor Research Domains: RNA Biology, Synaptic Plasticity, Neurodegeneration, Oncology Dr. Tiedge investigates how BC1 and BC200 RNAs regulate local protein synthesis in dendrites through interactions with eukaryotic initiation factors (eIF4A/B) . His work demonstrates that BC RNA dysregulation leads to neuronal hyperexcitability , epileptogenesis , and cognitive dysfunction , with therapeutic applications in neuropsychiatric lupus using RNA decoys. He also explores BC RNA expression in germ cells and tumors , aiming to develop diagnostic/prognostic tools for cancer. Key publications include studies on RNA transport via hnRNP A2 and Purα , autoantibody-induced RNA displacement , and cross-talk between BC RNAs and FMRP in fragile X syndrome. His work has been supported by NIH grants NS046769 and DA026110 .

Gerry CrossanView profile

Research Professor

• DNA damage and repair
• Genomic stability
• Germ-cell biology
• +4 more

Gerry Crossan is a programme leader at the MRC Laboratory of Molecular Biology (LMB), University of Cambridge, and concurrently serves as a Governing-Body Fellow and Research-Fellowships Secretary (STEM) at a Cambridge college, placing him at the intersection of cutting-edge research and academic governance. His research seeks to understand how genetic information is transmitted faithfully across generations, with a particular emphasis on the mechanisms that protect germ-line cells from DNA damage. Trained in DNA-interstrand-crosslink repair, he pioneered studies revealing how endogenous aldehydes—common by-products of metabolism and alcohol—create genotoxic stress, damage chromosomes and fuel stem-cell mutation. His work delineated the Fanconi anaemia DNA-repair pathway as a critical guardian against such damage, demonstrated that maternal aldehyde detoxification during pregnancy safeguards the fetal genome, and identified SLX4 as a key tumour-suppressor/nuclease regulator whose loss phenocopies Fanconi anaemia. More recently his programme has expanded to primordial-germ-cell biology, demonstrating that translesion DNA synthesis is essential for genome-wide demethylation and normal germ-cell development, and uncovering protective roles of Fanconi proteins against retrotransposon activity. Across more than two dozen high-impact publications (Nature, Nature Genetics, Molecular Cell, Blood) a clear trend emerges: integration of biochemical, genetic and whole-animal approaches to expose how everyday metabolites threaten genome integrity, how defined repair pathways counteract these threats, and how failure of such defences precipitates developmental abnormality, bone-marrow failure and cancer. These insights are already informing therapeutic strategies, exemplified by his proposal to repurpose metformin to mitigate aldehyde stress in Fanconi anaemia patients. Within Cambridge he contributes to collegiate governance and to the selection and mentoring of incoming research fellows, underlining his commitment to nurturing the next generation of scientists.

• Developmental Biology
• Evolutionary Biology
• Gene Expression Regulation
• +3 more

Claudia Mieko Mizutani is an Associate Professor in the Department of Biology at Case Western Reserve University. Her research focuses on understanding how gene expression patterns evolve to produce diverse tissues and life forms, using Drosophila melanogaster as a model organism. She combines genetic engineering, imaging, and computational modeling to investigate embryonic dorsal-ventral axis patterning and its evolutionary modifications. Research Interests: Investigating gene network evolution in conserved developmental systems Analyzing BMP signaling mechanisms in neuroectoderm patterning Comparing dorsal-ventral axis development across Drosophila species Quantifying transcriptional response dynamics Studying developmental time variation and scaling Exploring hybrid infertility through Evo-Devo perspectives Her laboratory has produced significant publications in fields spanning developmental biology, evolutionary genetics, and computational modeling. Notable contributions include work on morphogen gradient formation and the interaction between embryo morphology and signaling pathways. Scientific Awards: Selected cover feature for 2011 Developmental Biology publication Faculty of 1000 'Must Read' recommendation for 2006 PLoS Biology paper Dr. Mizutani's research integrates experimental and computational approaches to uncover fundamental mechanisms of developmental evolution while maintaining core functionality in biological systems.

Hugh ClarkeView profile

Professor

• Reproductive Biology
• Infertility
• Oocyte Development
• +3 more

Hugh Clarke, PhD is a Senior Scientist at the RI-MUHC, Glen site and a Professor in the Department of Obstetrics and Gynecology at McGill University 's Faculty of Medicine and Health Sciences. His research focuses on oocyte development within ovarian follicles. Research Interests: Oocyte growth and maternal molecule storage Germ cell-somatic cell communication Environmental toxin effects on oocyte quality Intercellular signaling mechanisms mRNA regulation during maturation Chromatin remodeling at fertilization Publications (2015-2024) reveal expertise in reproductive biology, with key projects examining: EGFR signaling in follicular decoupling mTOR pathway in follicle communication CNOT6-mediated mRNA deadenylation Transzonal projection architecture Epigenetic inheritance patterns Actin's role in meiotic processes Location: Lab F3-50, Royal Victoria Hospital, Montreal, QC H3A 1A1

Arminja N. KettenbachView profile

Professor

• Protein Phosphorylation
• Cellular Signaling Networks
• Cancer Biology
• +6 more

Dr. Arminja N. Kettenbach is a Professor of Biochemistry and Cell Biology at the Geisel School of Medicine, Dartmouth College. Her research focuses on protein phosphorylation and phosphatase functions in cellular signaling networks, particularly in cancer biology and triple-negative breast cancer (TNBC). Master's in Biochemistry, Eberhard-Karls University Tuebingen (2002) PhD in Cell Biology, Harvard Medical School (2003-2007) Postdoctoral studies in Genetics, Geisel School of Medicine (2007-2011) Her lab combines quantitative proteomics and phosphoproteomics with in vitro reconstitution to uncover phosphatase-substrate relationships, opposing kinases, and regulatory mechanisms in mitosis and cancer. She pioneered methods for phosphopeptide enrichment and kinase substrate motif determination. Her publications highlight work on cyclin-dependent kinases, Aurora/Polo-like kinases, PP6 phosphatase, and fission yeast signaling pathways. Her research spans biochemistry, cell biology, and cancer biology, emphasizing phosphorylation dynamics and network modeling. Grants include NIH/NIGMS R35 GM119455 and P20 GM113132, and The V Foundation for Cancer Research funding. She teaches courses in biochemical medicine and molecular biology, serving as a lecturer and discussion group leader.

• Male Infertility
• Oxidative Stress
• Proteomics
• +3 more

Dr. Ahmet Ayaz is an Associate Research Scientist at Yale School of Medicine's Department of Obstetrics, Gynecology & Reproductive Sciences. His research focuses on male infertility mechanisms, particularly the roles of oxidative stress, proteomics, and environmental factors. He has contributed to multicenter studies on semen analysis standardization and biomarker identification for male infertility. His work spans clinical, translational, and basic science domains, including proteomic signatures of sperm dysfunction and the impact of redox imbalance on fertility. He collaborates with the Fertility Center and other interdisciplinary teams to advance reproductive health research. Research Interests: Dr. Ayaz investigates how oxidative stress and environmental exposures influence sperm biology and male fertility. His studies employ proteomic techniques to identify biomarkers associated with infertility, including varicocele, reactive oxygen species (ROS), and chromatin abnormalities. He also explores the clinical utility of assays like oxidation-reduction potential (ORP) in predicting infertility outcomes and embryo quality. Key Research Trends: Recent articles highlight advancements in understanding sperm protein alterations, epigenetic variations in germ cells, and the societal implications of vasectomy reversal trends. His work bridges basic science (e.g., chromatin bivalency mechanisms) with clinical applications (e.g., standardized semen analysis protocols for toxicology studies). Awards: None explicitly listed in provided materials. Advising & Grants: While formal student advisement details are unreported, his extensive publication record suggests active mentorship in lab settings. Grant funding details are not detailed in the text. Labs/Teams: Collaborates with the Fertility Center and interdisciplinary groups at Yale School of Medicine, focusing on translational research in reproductive medicine.

• Human Germline Gene Editing
• Genomics
• Public Engagement
• +7 more

Dr. Sam Riedijk is an Associate Professor in the Department of Clinical Genetics at Erasmus MC, where he conducts research at the intersection of genomics, ethics, and public policy. His work emphasizes public engagement, decision-making, and the societal implications of human germline gene editing. Research Interests: His primary research areas include human germline gene editing, genetic counseling, genomics, public and stakeholder engagement, ethical decision-making, and policy development. His fingerprint reveals strong activity in Germline , Germ Cell , Genome Editing , Exome Sequencing , and Coping Behavior , reflecting a transdisciplinary approach to clinical genetics and bioethics. Publication Trends: Over the past few years, Dr. Riedijk has focused on the ethical and societal dimensions of gene editing, particularly the need for structured public dialogues, goal specification, and inclusive policy-making. His recent publications highlight a shift toward participatory models in science governance and the importance of patient and public perspectives in shaping genetic technologies. Scientific Awards: No awards listed in the provided text. Advising and Grants: Dr. Riedijk has supervised at least one doctoral thesis, indicating an active role in mentoring. He is involved in collaborative research through the DNA Dialogues Consortium, suggesting participation in funded, multi-institutional projects focused on public engagement in genetics. While specific grants are not listed, his frequent co-authorship in high-impact journals indicates sustained research funding. Labs and Teams: He is affiliated with the DNA Dialogues Consortium, a transdisciplinary team dedicated to public engagement on genetic technologies. This consortium brings together experts from clinical genetics, ethics, social sciences, and policy to facilitate democratic dialogue on genome editing.

Ayşegül DoğanView profile

Associate Professor

• Biology
• Molecular Biology
• Cell Biology
• +5 more

Dr. Ayşegül Doğan is an Associate Professor in the Department of Genetics and Bioengineering at Yeditepe University's Faculty of Engineering, with promotion to full Professor scheduled for 2025. Her academic journey began with dual undergraduate degrees in Biology and Molecular Biology and Genetics at Istanbul University, followed by Master's and PhD studies in Biotechnology at Yeditepe University. Her educational background includes: PhD in Biotechnology (2011-2015), Yeditepe University - Thesis: "A novel chemotherapeutic drug combination for prostate cancer" Master's in Biotechnology (2009-2011), Yeditepe University - Thesis: "Effect of P85, F68 and F127 pluronic block copolymers on osteogenic, chondrogenic and adipogenic differentiation of human tooth germ stem cells (HTGSCs)" Undergraduate degrees in Biology and Molecular Biology and Genetics (2005-2009), Istanbul University Dr. Doğan's research spans multiple frontiers of stem cell biology and regenerative medicine. Her work particularly focuses on: Stem cell differentiation mechanisms and signaling pathways Organoid development for regenerative medicine applications Boron compounds in wound healing and tissue regeneration Cancer treatment using novel drug combinations Stem cell applications in reproductive medicine and endocrinology Analysis of her recent publications reveals an increasing emphasis on stem cell-derived organoids, with particular expertise in parathyroid function, adipose tissue engineering, and neural differentiation. Her research demonstrates sophisticated approaches to creating functional tissue models from pluripotent stem cells, with strong translational potential. Her scientific recognition includes: Multiple patents related to stem cell technology and wound healing formulations Patent Bronze Medal from ISIF and Turkish Patent Institute TÜBA-GEBİP award from the Turkish Academy of Sciences Department and Faculty First Prizes from Istanbul University Dr. Doğan actively mentors graduate students, with seven Master's and PhD theses completed under her supervision in recent years. She serves as principal investigator for multiple research projects funded by TÜBİTAK and other institutions, with current work focusing on stem cell applications in regenerative medicine. Her laboratory develops novel stem cell-based therapies and tissue engineering approaches, with particular emphasis on neuromesodermal progenitors and their therapeutic applications. She maintains active membership in professional organizations including the London Stem Cell Network, AACR, and the International Society for Stem Cell Research (ISSCR).

Allen FengView profile

Research Fellow

• Developmental Biology
• Reproductive Biology
• Molecular Biology
• +3 more

Dr Allen Feng is a postdoctoral research fellow at the School of Biomedical Sciences , The University of Queensland. He is affiliated with the Bowles group , specializing in developmental reproductive biology. His research focuses on germ cell regulation, gonadal development, and signaling pathways in mammalian and avian models. Bachelor of Science (The University of Queensland) Bachelor (Honours) of Science (Advanced) (The University of Queensland) Doctor of Philosophy (The University of Queensland, 2016) Allen's research spans Developmental Biology , Genetics , and Molecular Biology , with key contributions to understanding meiosis regulation, retinoic acid signaling, and transcriptional control in germ cell development. His work includes studies on SOX30's role in male fertility and STRA8 expression in ovarian germ cells. Recent articles highlight his expertise in germ cell fate determination , retinoic acid metabolism , and transgenic models for developmental studies. He has contributed to virology through plant virus diagnostics but primarily focuses on biomedical sciences. Scientific awards include the Ian Potter Foundation Travel Grant (2017) for SOX30 research. Allen is available for supervision and collaborates with teams exploring gonadal development and reproductive health.

Gregory J. HannonView profile

Professor

• Small RNA Biology
• RNA Interference
• Cancer Biology
• +7 more

Gregory J. Hannon is a distinguished Professor at Cold Spring Harbor Laboratory (CSHL) and an Investigator of the Howard Hughes Medical Institute, renowned as one of the world's foremost authorities on small RNA biology and RNA interference. His research has significantly advanced our understanding of gene regulation mechanisms with profound implications for cancer treatment and genome stability. Hannon's educational background includes training that led to his current position as a leading molecular biologist. His research focuses on the biological roles of small RNAs and the mechanisms by which they operate, with particular emphasis on germ cells (which have the most elaborate set of small RNA pathways) and cancer biology (especially breast and pancreatic cancer). His laboratory's groundbreaking work has identified and characterized major biogenesis and effector complexes for small interfering RNAs and microRNAs, including Dicer, RISC, and elements of the Microprocessor. More recently, his team has made significant discoveries regarding piwi-interacting RNAs (piRNAs) and their role in defending the genome from mobile genetic elements. Among his most significant publications are studies on the structure of human Argonaute protein, mechanisms of transposon defense in germ cells, and how breast tissue 'remembers' a first pregnancy through epigenetic changes. His research has consistently appeared in top-tier journals, with several publications recognized by Science as 'Breakthrough of the Year.' Elected to National Academy of Sciences (2012) NIH MERIT Award from National Institute of General Medical Sciences (2013) National Academy of Sciences Award in Molecular Biology (2007) Geoffrey Marshall Mentoring Award from Northeastern Association of Graduate Schools (2011) Howard Hughes Medical Institute Investigator Hannon has mentored 12 postdoctoral fellows and 17 graduate students, with exceptional outcomes including multiple prestigious awards for his trainees. Over 60% of his 200+ publications include graduate student co-authorship. His laboratory has developed innovative technologies including RNAi libraries targeting entire genomes and methods used in Neanderthal genome sequencing. He also serves as director of the Cancer Research UK Cambridge Institute, demonstrating his international leadership in cancer research.

• Epigenetics
• Molecular Biology
• Genetics
• +3 more

Mariateresa Mazzetto is an Associate Research Scientist in Genetics at Yale University's Yale School of Medicine, Department of Genetics. She works under Prof. Valerie Reinke, focusing on epigenetic mechanisms in C. elegans and aging studies using turquoise killifish. Her research bridges molecular genetics, developmental biology, and aging science. Key projects include analyzing epigenetic pathways in germline development and transcriptomic signatures of heritable lifespan differences in killifish strains. Collaborations span with Prof. Reinke and Prof. Cellerino, exploring topics like chromatin dynamics, neurogenesis, and proteasomal dysfunction in aging. Publications highlight expertise in transcriptomics, epigenetic regulation, and neurobiological aging mechanisms. While no formal awards are listed, her work contributes to understanding fundamental biological processes in aging and development through interdisciplinary approaches.

Eamonn MaherView profile

Professor

• Genetics
• Oncology
• Neoplasm
• +7 more

Professor Eamonn Maher is the Dean of Aston Medical School at Aston University, within the College of Health and Life Sciences. His primary affiliation is with the School of Life & Health Sciences, where he leads research in genetic oncology and rare diseases. His work focuses on understanding the genetic basis of neoplasms, particularly in syndromes like von Hippel-Lindau disease, Birt-Hogg-Dubé syndrome, and hereditary renal cell carcinoma. He has published extensively on topics including genotype-specific cancer risk profiling, molecular diagnostics, and clinical guideline development. Research Interests: Professor Maher's expertise spans cancer genetics, inherited predispositions to tumors, and the molecular mechanisms of genetic disorders. Key areas include: Neoplastic risk profiling in hereditary syndromes Genomic analysis of renal and endocrine tumors Clinical management of phaeochromocytoma/paraganglioma Imprinting disorders and epigenetic mechanisms Public health implications of rare kidney diseases Recent Work Trends: His 2024–2025 publications emphasize: Advances in whole-genome sequencing for rare tumor diagnosis Systematic reviews of multiple primary renal tumors Guideline development for pediatric phaeochromocytoma/paraganglioma Genomic epidemiology of Birt-Hogg-Dubé syndrome Collaborations: His international collaborations include studies on SDHx-deficient cancers, multi-locus imprinting disturbances, and the UK National Registry of Rare Kidney Diseases (RaDaR). He also contributes to initiatives like the ClinGen VHL Variant Curation Expert Panel and ERN GENTURIS. Grants & Labs: While specific grants are not listed, his leadership in RaDaR and involvement in international registries indicate significant grant-funded research. His lab focuses on translational research bridging genetic discovery and clinical practice.

• RNA Splicing
• Molecular Genetics
• Alternative Splicing Mechanisms
• +5 more

Professor David Elliott is a leading researcher in molecular genetics at Newcastle University's Institute of Genetic Medicine. With over two decades of research experience, he has established himself as an expert in RNA splicing mechanisms and their role in human diseases, particularly prostate cancer and developmental disorders. His research focuses on the molecular mechanisms of alternative splicing, with particular emphasis on: RNA binding proteins and their role in tissue-specific splicing regulation Splicing dysregulation in prostate cancer pathogenesis and progression Germ cell development and male fertility mechanisms Neurodevelopmental processes and associated genetic disorders Glycosylation pathways and their intersection with splicing regulation in cancer Professor Elliott's work demonstrates how alterations in RNA processing contribute to disease pathogenesis, with significant implications for developing novel therapeutic approaches. His research spans from fundamental molecular mechanisms to translational applications, particularly in cancer treatment. His laboratory has made significant contributions to understanding how: Splicing factors like Tra2β regulate tissue-specific alternative splicing events Glycosylation enzymes influence cancer cell behavior and treatment response RNA binding protein networks maintain proper gene expression during development Genetic variants in splicing regulators lead to neurodevelopmental disorders Professor Elliott has received continuous research funding and has trained numerous PhD students and postdoctoral researchers who have gone on to successful careers in academia and industry. His work is frequently published in high-impact journals and has influenced the direction of research in RNA biology and cancer genetics.

Angela StathopoulosView profile

Professor

• Developmental Biology
• Genetics
• Systems Biology
• +3 more

Angela Stathopoulos is a Professor in the Division of Biology & Biological Engineering at the California Institute of Technology (Caltech), where she has led her research laboratory for 18 years. She also serves as the Director of the Center for Molecular and Cellular Neuroscience, a position she has held since 2024. Her educational background includes: B.A. from the University of California (1992) Ph.D. from Stanford University (1998), where she studied calcium signaling and calcineurin phosphatase regulated gene expression under Martha Cyert Postdoctoral training at UC Berkeley in Mike Levine's laboratory, using Drosophila as a model system to study transcriptional regulation Dr. Stathopoulos employs a systems-level approach to study embryonic development, integrating cis-regulatory and cell biological data with quantitative measures. Her research focuses on how transcription factors and signaling pathways influence cells to regulate changes in cell shape and form during development. She has made significant contributions to understanding transcriptional regulation, embryonic patterning, and collective cell migration, particularly with the identification of the caudal visceral mesoderm (CVM) as a new collective cell migration model system. Her lab recently incorporated optogenetic approaches to study the dynamic action of transcription factors. The collective body of her recent publications demonstrates a strong focus on developmental mechanisms in Drosophila , with particular emphasis on transcriptional regulation, enhancer function, and cell migration. Her work spans multiple techniques including genetics, biochemistry, live in vivo imaging, and quantitative analysis, reflecting her systems biology approach to developmental questions. Dr. Stathopoulos leads the Stathopoulos Lab at Caltech, which maintains active research programs in embryonic gene expression, enhancer action, fibroblast growth factors, and cell migration. The lab website indicates ongoing investigations into the timing of embryonic gene expression, coordinate action of enhancers, individual functions of fibroblast growth factors, and collective cell migration mechanisms.

Lay Teng AngView profile

Assistant Professor

• Stem Cell Biology
• Developmental Biology
• Regenerative Medicine
• +4 more

Lay Teng Ang is an Assistant Professor of Urology at Stanford University, with concurrent appointments at the Bio-X , Cardiovascular Institute , and Institute for Stem Cell Biology & Regenerative Medicine . His research focuses on stem cell differentiation mechanisms and their applications in vascular biology, hematopoiesis, and neuroinflammation. Doctoral training at University of Cambridge and A*STAR Professional background includes Genome Institute of Singapore and Stanford Institute for Stem Cell Biology Research interests span pluripotent stem cell lineage specification , endothelial cell heterogeneity , and therapeutic targeting of EPAS1/ACKR1 pathways . His work has produced protocols for generating highly pure hematopoietic progenitors and organ-specific endothelial cells . Key publications include: 2025: Venous dysfunction in vascular dementia (Nature Communications) 2024: Hematopoietic stem cell lineage tracing (Developmental Cell) 2023: Germ cell specification mechanisms (Nature Communications) 2022: Meningococcal disease susceptibility via CFHR3 variation (AJHG) Awards include Catalyst to Independence and Siebel Investigatorship grants, with affiliations spanning the American Heart Association and Stanford Maternal & Child Health Research Institute .