David Elliott

Professor David Elliott is a leading researcher in molecular genetics at Newcastle University's Institute of Genetic Medicine. With over two decades of research experience, he has established himself as an expert in RNA splicing mechanisms and their role in human diseases, particularly prostate cancer and developmental disorders.

His research focuses on the molecular mechanisms of alternative splicing, with particular emphasis on:

• RNA binding proteins and their role in tissue-specific splicing regulation
• Splicing dysregulation in prostate cancer pathogenesis and progression
• Germ cell development and male fertility mechanisms
• Neurodevelopmental processes and associated genetic disorders
• Glycosylation pathways and their intersection with splicing regulation in cancer

Professor Elliott's work demonstrates how alterations in RNA processing contribute to disease pathogenesis, with significant implications for developing novel therapeutic approaches. His research spans from fundamental molecular mechanisms to translational applications, particularly in cancer treatment.

His laboratory has made significant contributions to understanding how:

• Splicing factors like Tra2β regulate tissue-specific alternative splicing events
• Glycosylation enzymes influence cancer cell behavior and treatment response
• RNA binding protein networks maintain proper gene expression during development
• Genetic variants in splicing regulators lead to neurodevelopmental disorders

Professor Elliott has received continuous research funding and has trained numerous PhD students and postdoctoral researchers who have gone on to successful careers in academia and industry. His work is frequently published in high-impact journals and has influenced the direction of research in RNA biology and cancer genetics.