Pere Puigserver

Pere Puigserver, Ph.D., is a Professor of Cell Biology at Harvard Medical School (HMS) and Dana-Farber Cancer Institute, where he holds dual appointments. He earned his Ph.D. in Biochemistry from UIB (Spain) and conducted postdoctoral research at Dana-Farber Cancer Institute. After joining the faculty at Johns Hopkins University School of Medicine in 2002, he returned to HMS and Dana-Farber in 2006. His research focuses on the molecular mechanisms underlying mitochondrial biology, intermediary metabolism, and cancer metabolism. The Puigserver Lab employs multidisciplinary approaches, including chemical genetics, metabolomics, proteomics, and mouse models, to study metabolic diseases and cancer biology.

• Education: Ph.D. in Biochemistry from UIB (Spain), postdoctoral training at Dana-Farber Cancer Institute.
• Research Interests: Mitochondrial energetics, metabolic adaptation to stress, cancer metabolism, and metabolic therapies.

Notable research areas include mitochondrial respiratory complex regulation, brown adipose thermogenesis, and drug targeting of metabolic pathways in cancer and diabetes. The lab's work bridges basic science and translational medicine, with recent efforts on small molecules modulating metabolic enzymes and mitochondrial function.

Grants: Puigserver leads NIH-funded projects on mitochondrial protein translation, cristae biogenesis, and anti-diabetic therapeutics. Recent grants include R01AG086369 (mitoribosome signaling) and R01DK136640 (cristae biogenesis).

Labs/Teams: The Puigserver Lab collaborates widely, integrating biochemical, genetic, and computational methods to address metabolic diseases. Key collaborations involve cancer metabolism, mitochondrial dysfunction, and pharmacological interventions.