Lawrence Allen Donehower

Lawrence Allen Donehower is a Professor in the Department of Molecular Virology and Microbiology at Baylor College of Medicine, Houston, USA. He is also a member of the Dan L Duncan Comprehensive Cancer Center. His research focuses on tumor suppressor genes, particularly p53, and their roles in cancer development, signaling pathways, and genomic integrity. Dr. Donehower's work includes mouse model systems to study p53 deficiency's impact on tumorigenesis and collaborations with genomic centers for large-scale cancer data analysis.

Education: Ph.D. from George Washington University (1981), B.S. from University of Maryland (1974).

Research Interests: Tumor suppressor genes (p53, PPM1D), DNA damage response, cancer genomics, computational analysis of cancer signaling patterns, and molecular mechanisms linking p53 to aging/longevity.

Publications: Recent work includes genomic analyses of DNA repair deficiencies, TP53 pathway alterations, and PPM1D's role in clonal hematopoiesis. Earlier studies established foundational knowledge on p53's role in cancer prevention and mouse model systems.

Affiliations: Collaborates with the Human Genome Sequencing Center and The Cancer Genome Atlas consortium.