Luis Martinez

Luis Martinez is an Associate Professor in the Department of Pathology at Stony Brook University's Renaissance School of Medicine. His research focuses on the oncogenic mechanisms of mutant p53, particularly its interactions with transcription factors like ETS2 and roles in tumor suppression and progression.

• Education: B.A. in Biological Sciences (1994) and Ph.D. in Biology (1998) from the University of Texas at Austin.

Dr. Martinez's work has uncovered critical gain-of-function (GOF) activities of mutant p53, including its role in stabilizing ETS2 to amplify oncogenic gene regulation. His recent studies explore p53's engagement with DNA sensing pathways and immune signaling in cancer.

Publications highlight his contributions to understanding mutant p53's impact on chemotherapy resistance, nucleotide metabolism, and immune suppression in tumors. These studies span molecular biology, cancer genetics, and biochemical regulation.

His laboratory continues to dissect the transcriptional networks and protein interactions that drive mutant p53-mediated tumorigenesis, with implications for targeted cancer therapies.