About
Jacob Reimer is an Assistant Professor of Neuroscience at Baylor College of Medicine, where he leads the Reimer Lab. His research focuses on understanding brain state changes, neuromodulation, and their effects on sensory processing and behavior. He has established important methodologies for monitoring brain states through pupillometry in mice and conducts cutting-edge research on neuromodulatory systems using advanced imaging techniques.
Dr. Reimer received his PhD in Neuroscience from the University of Chicago in 2009.
Dr. Reimer's research spans multiple areas of systems and computational neuroscience. His lab investigates the mechanisms underlying fast brain state changes and their downstream effects on sensory processing. A key focus is on neuromodulation, particularly studying acetylcholine, norepinephrine, dopamine, and serotonin dynamics in the cortex. His work employs high-resolution two-photon imaging to examine how these neuromodulators function across different behavioral states, during aging, and in Alzheimer's disease models. The lab also develops computational tools for connectomics analysis and investigates the relationship between neural structure and function in visual and olfactory systems.
Analysis of Dr. Reimer's recent publications reveals a strong focus on neuromodulation dynamics, particularly acetylcholine and norepinephrine, using advanced imaging techniques. His work bridges multiple scales from molecular and cellular dynamics to systems-level brain function, with significant contributions to understanding brain state transitions through pupillometry. The research spans diverse model systems including mouse, primate, and cross-species comparisons, with growing emphasis on translational applications in aging and Alzheimer's disease.
Dr. Reimer's lab receives substantial funding from multiple NIH grants including R01 NS128901 (The Spatial and Temporal Scale of Neuromodulation), R56 AG080735 (The Dynamic Neuromodulome in Alzheimer's Disease and Aging), R34 NS137454 (Cross-Species comparison of cholinergic neuromodulation), and U01 NS137250 (BRAIN CONNECTS: A Scalable Automated Proofreading Framework for Connectomics). He also secured an S10 OD038398-01 grant for a $1M+ Femtonics microscope for the Neuroscience department.
The Reimer Lab consists of a multidisciplinary team including graduate students, postdoctoral associates, research technicians, and scientific programmers. Current lab members include Mario A. Galdamez, Noura Z. Hakam, Ming Hu, Andre Mwangi Kirunda, Ryan J. Kroeger, Rob George Law, Erin Neyhart, Yu-Yau Shan, Cameron Lewis Smith, and Elizabeth Straley (Lab Manager). The lab collaborates extensively with other researchers at Baylor College of Medicine and beyond, including Jeannie Chin, Valentin Dragoi, Andreas Tolias, and Francois St-Pierre.
