Frank F. Soldner

Frank F. Soldner, M.D., is an Assistant Professor in the Dominick P. Purpura Department of Neuroscience and Department of Genetics at Albert Einstein College of Medicine. His research focuses on neurodegenerative diseases, particularly Parkinson's, using innovative approaches combining induced pluripotent stem cells (iPSCs), CRISPR/Cas9 genome editing, and systems biology. He develops patient-specific cellular models to study disease mechanisms and identify therapeutic targets.

Key research areas include: (1) Functional analysis of genetic risk variants in non-coding regions, (2) Epigenetic regulation in disease progression, (3) High-throughput screening of compounds using engineered neurons, and (4) 3D organoid models for neurodegenerative disorders. His work bridges basic science and translational medicine, emphasizing disease modeling with genetic precision.

Publications highlight contributions to α-synuclein toxicity mechanisms, CRISPR-based disease modeling, and single-cell epigenetic analysis. His lab collaborates extensively with genomic databases and employs cutting-edge tools like genome-scale screens to uncover disease pathways. Current studies investigate lipidomic changes in Parkinson's and mitochondrial quality control mechanisms.