Herbert M. Lachman

Dr. Herbert M. Lachman is a Professor at the Albert Einstein College of Medicine, holding positions in the Departments of Psychiatry and Behavioral Sciences, Medicine (Oncology & Hematology), Neuroscience, and Genetics. A physician and behavioral geneticist, his research focuses on the molecular and genetic basis of schizophrenia, autism spectrum disorders, bipolar disorder, and intellectual disabilities. He employs induced pluripotent stem cell (iPSC) technology to model neuropsychiatric disorders, studying neurogenesis, gene expression, and environmental factors like immune system involvement in diseases such as PANS.

Education & Clinical Background:

• M.D. from New York Medical College
• Fellowship at Montefiore Medical Center
• Residency at Metropolitan Hospital

Research Interests: Dr. Lachman’s lab uses iPSC-derived neurons, cerebral organoids, and CRISPR-Cas9 gene editing to analyze schizophrenia, autism, and 22q11.2 deletion syndrome. Recent work explores environmental influences like pesticide exposure and immune dysfunction in neuropsychiatric disorders. Key areas include epigenetic analysis, transcriptomics, and proteomics in patient-specific models.

Article Trends: Publications emphasize iPSC-derived models, CRISPR knockout studies of autism genes (e.g., CHD8), and the role of microglia in neurodevelopmental disorders. Recent work highlights Jansen de Vries Syndrome proteomics and PANS genetic variants.

Grants & Awards: No awards listed, but his NIH-funded research includes collaborations on neurodevelopmental and psychiatric disorders. Advising details are unspecified.

Labs & Teams: His lab collaborates across departments at Einstein, focusing on interdisciplinary approaches to neuropsychiatric disease modeling and genetic mechanisms.